中國(guó)藥科大學(xué)

陳君，女，博士，副教授，博士研究生導(dǎo)師。2000年7畢業(yè)于中國(guó)藥科大學(xué)中藥制藥專業(yè)，獲學(xué)士學(xué)位；2006年7月畢業(yè)于中國(guó)藥科大學(xué)生藥學(xué)專業(yè)，獲博士學(xué)位，并留校任教。現(xiàn)為生藥學(xué)藥用植物學(xué)教研室主任。

主要從事中藥活性成分發(fā)現(xiàn)與質(zhì)量評(píng)價(jià)研究，主要通過建立基于親和色譜、液相色譜-質(zhì)譜聯(lián)用技術(shù)、生物技術(shù)的新方法、新技術(shù)，發(fā)現(xiàn)與評(píng)價(jià)中藥復(fù)雜體系中活性成分（群），進(jìn)而闡明中藥藥效物質(zhì)、開展中藥質(zhì)量標(biāo)準(zhǔn)及新藥開發(fā)研究。

主持國(guó)家自然科學(xué)基金項(xiàng)目3項(xiàng)（面上項(xiàng)目：基于丹參酮小分子探針研究其抗血管內(nèi)皮細(xì)胞氧化應(yīng)激損傷的分子靶標(biāo)及調(diào)控機(jī)制81573705；面上項(xiàng)目：多靶垂釣/成分在線捕獲方法的建立及在抗老年癡呆中藥藥效物質(zhì)群研究中的應(yīng)用81073006；青年科學(xué)基金項(xiàng)目：高效液相偶聯(lián)自由基捕獲檢測(cè)系統(tǒng)用于中藥抗氧化效應(yīng)評(píng)價(jià)及其物質(zhì)基礎(chǔ)研究30801521），入選教育部“新世紀(jì)優(yōu)秀人才支持計(jì)劃”；完成了2010年版《中國(guó)藥典》山銀花、萹蓄等品種的質(zhì)量標(biāo)準(zhǔn)起草；作為研究骨干參與國(guó)家自然科學(xué)基金創(chuàng)新群體項(xiàng)目、重點(diǎn)項(xiàng)目和國(guó)家重大科技專項(xiàng)“重大新藥創(chuàng)制”等課題的研究工作，為教育部創(chuàng)新團(tuán)隊(duì)、江蘇省創(chuàng)新團(tuán)隊(duì)的主要成員。近五年來，在Journal of Chromatography A、Analytical Bioanalytical Chemistry、Journal of Functional Foods等國(guó)際雜志發(fā)表SCI收錄論文34篇，獲授權(quán)發(fā)明專利7項(xiàng)。獲2013年度教育部自然科學(xué)一等獎(jiǎng)（排名第四），2009年度國(guó)家科學(xué)技術(shù)進(jìn)步二等獎(jiǎng)（排名第九），2007年度教育部自然科學(xué)一等獎(jiǎng)（排名第九）。指導(dǎo)本科生完成的作品獲第十二屆“挑戰(zhàn)杯”全國(guó)大學(xué)生課外學(xué)術(shù)科技作品競(jìng)賽江蘇省三等獎(jiǎng)，指導(dǎo)本科生開展的國(guó)家大學(xué)生創(chuàng)新性實(shí)驗(yàn)計(jì)劃項(xiàng)目入圍第四屆全國(guó)大學(xué)生創(chuàng)新年會(huì)學(xué)術(shù)論文大賽（2011年）。

研究成果

1、10篇代表性論文（*為通訊作者）：

1)Jing Liu, Li-Ping Luo, Hui Zhang, Bing-Jie Jia, Jin-Jin Lu, Ping Li, Jun Chen*. Rapid screening for nover antioxidants in Glycyrrhiza inflata using high-resolution peak fractionation. Journal of Functional Foods, 2015, 16:40-49.
2)Hui Zhang, Li-Ping Luo, Hui-Peng Song, Hai-Ping Hao, Ping Zhou, Lian-Wen Qi, Ping Li*, Jun Chen*. A high-resolution peak fractionation approach for streamlined screening of NF-E2-related factor-2 activators in Salvia miltiorrhiza. Journal of Chromatography A, 2014, 1326:47-55.
3)Yu Fu, Huan-Yan Mo, Wen Gao, Jia-Ying Hong, Jun Lu, Ping Li*, Jun Chen*. Affinity selection-based two-dimensional chromatography coupled with high-performance liquid chromatography-mass spectrometry for discovering xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae. Analytical Bioanalytical Chemistry, 2014, 406(20):4987-95.
4)Jun Lu, Hui-Peng Song, Ping Li*, Ping Zhou, Xin Dong, Jun Chen*. Screening of direct thrombin inhibitors from Radix Salviae Miltiorrhizae by a peak fractionation approach. Journal of Pharmaceutical and Biomedical Analysis, 2015, 109:85-90.
5)Hui-Peng Song, Hui Zhang, Yu Fu, Hua-Yan Mo, Mu Zhang, Jun Chen*, Li Ping*. Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC-MS combined with enzyme channel blocking. Journal of Chromatography B, 2014, 961:56-61.
6)Yu Fu, Jun Chen*, Yan-Jing Li, Yun-Feng Zheng, Ping Li*. Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. Food Chemistry, 2013, 141:1064-1071.
7)Wen Gao, Hua Yang, Lian-Wen Qi, E-Hu Liu, Mei-Ting Ren, Yu-Ting Yan, Jun Chen*, Ping Li*. Unbiased metabolite profiling by liquid chromatography- quadrupole time-of-flight mass spectrometry and multivariate data analysis for herbal authentication: classification of seven Lonicera species flower buds. Journal of Chromatography A, 2012, 1245:109-116.
8)Yan-Jing Li, Jun Chen*, Ying Li, Qin Li, Yun-Feng Zheng, Yu Fu, Ping Li*. Screening and charactrerization of natural antioxidants in four Glycyrrhiza species by liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Journal of Chromatography A, 2011, 1218:8181-8191.
9)Mei-Ting Ren, Jun Chen*, Song Yue, Long-Sheng Sheng, Li Ping*, Lian-Wen Qi. Identification and quantification of thirty-two bioactive compounds in Lonicera species by high performance liquid chromatography coupled with time-of-flight mass spectrometry. Journal of Pharmaceutical & Biomedical Analysis. 2008, 48:1351-1360.
10)Yan-Jing Li, Huan-Li Wei, Lian-Wen Qi, Jun Chen*, Mei-Ting Ren, Ping Li*. Characterization and identification of saponins in Achyranthes bidentata by rapid-resolution liquid chromatography with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 2010, 24:2975-2985.

2、專利：

1)丹酚酸C在制備防治高尿酸血癥藥物中的應(yīng)用.陳君，李萍，高雯.ZL201210000772.6.已授權(quán).
2)一種黃酮化合物預(yù)防或治療炎癥性疾病的用途.陳君，李萍，李艷靜，付鈺.ZL201110398561.8.已授權(quán).
3)一種黃酮化合物在制備預(yù)防或治療腫瘤藥物中的用途..陳君，李萍，王一方，劉靜，付鈺，鄭云楓.ZL201310112169.1.已授權(quán).
4)一種常春藤皂苷、其制備方法及其抗腫瘤用途.李萍,陳君,湯丹.ZL200710135566.5.已授權(quán).
5)一種適用于天然產(chǎn)物高通量篩選的化合物庫(kù)高效制備方法.李萍,陳君,張慧,羅麗平,宋慧鵬,周萍.2013100326266,已申請(qǐng).
6)丹參新酮在制備保護(hù)血管內(nèi)皮細(xì)胞的藥物中的用途.陳君,李萍,羅麗平,張慧,宋慧鵬,周萍,劉鄂湖.201310128667.5,已申請(qǐng).
7)青蒿素及青蒿琥酯抗阿爾茨海默病的醫(yī)療用途.李萍，陳君，徐曉軍，王菊，石子琪.201210380878.3,已申請(qǐng).

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