中國藥科大學

楊蕾，女，博士，1980年5月生，中國藥科大學天然藥物化學教研室副教授。主要承擔本科生天然藥物化學課程、研究生天然物結構化學課程的教學工作。2003年中國藥科大學生物技術專業本科畢業。2008年中國藥科大學微生物與生化藥學博士畢業，導師吳梧桐教授。2011年中國藥科大學中藥學院博士后出站，導師孔令義教授。主要研究方向為天然產物的高通量藥物篩選體系的建立、中藥及天然藥物的活性成分和機制研究、基于生物酶反應的生物轉化研究。具體內容包括抗腫瘤藥物的篩選和機制研究、逆轉腫瘤多藥耐藥性的藥物篩選和機制研究等。

聯系方式：Tel：025-83271402,Email：dorothy19802003@163.com

通信地址：南京市童家巷24號，中國藥科大學天然藥物化學教研室，郵編210009。

主持的科研項目:

中國藥科大學引進人才基金

2011-2012中央高校基本科研業務費培育項目（P-gp高表達骨肉瘤多藥耐藥細胞模型的建立及中藥中相關新型逆轉劑的篩選，項目批準號：JKP2011014，8萬）

2013-2015國家自然科學基金（逆轉P-gp介導的骨肉瘤細胞多藥耐藥性作用中藥的篩選及其機制研究，項目批準號：81202901，22萬）

近期代表性論文：

Geng, Y.D., Yang, L. (Co-first author), Zhang, C., Kong, L.Y. 2014. Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells. Food Chem. Toxicol. 73. 7-16.

Hu, S.M., Luo, J., Yang, L. (co-corresponding author), Kong, L.Y. 2014.Exploration of possible biosynthetic origin of 1/8/9-orthoester moiety in phragmalins. Tetrahedron Letters. 55, 815-817.

Wu, L., Luo, J., Zhang, Y., Wang, X., Yang, L. (co-corresponding author), Kong, L.Y. 2014. Cassane-type diterpenoids from the seed kernels of Caesalpinia bonduc. Fitoterapia. 93, 201-208.

Zhang, C., Yang, L., Wang, X.B., Wang, J.S., Geng, Y.D., Yang, C.S., Kong, L.Y. 2013. Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells. Cancer Lett. 340, 51-62.

Guo, C., Wang, J.S., Zhang, Y., Yang, L., Wang, P.R., Kong L.Y. 2012. Relationship of chemical structure to in vitro anti-inflammatory activity of tirucallane triterpenoids from the stem barks of Aphanamixis grandifolia. Chem Pharm Bull. 60, 1003-1010.

Yang, L., Wei, D.D., Chen, Z., Wang, J.S., Kong, L.Y. 2011. Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum. Phytomedicine. 18, 710-718.

Yang, L., Wei, D.D, Chen, Z., Wang, J.S., Kong, L.Y. 2011. Reversal effects of traditional Chinese herbs on multidrug resistance in cancer cells. Nat Prod Res. 25, 1885-1889.

Yang, L., Jiang, C., Liu, F., You, Q.D., Wu, W.T. 2008. Cloning, enzyme characterization of recombinant human Eg5 and the development of a new inhibitor. Biol Pharm Bull. 31, 1397-1402.

Jiang, C., Yang, L. (Co-first author), Wu, W.T., Guo, Q.L., You, Q.D. 2011. CPUYJ039, a newly synthesized benzimidazole-based compound, is proved to be a novel inducer of apoptosis in HCT116 cells with potent KSP inhibitory activity. J Pharm Pharmacol. 63, 1462-1469.

Jiang, C., Yang, L., Wu, W.T., Guo, Q.L., You, Q.D. 2011. De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. Bioorg Med Chem. 19, 5612-5627.

Fu, R.G., You, Q.D., Yang, L., Wu, W.T., Jiang, C., Xu, X.L. 2010. Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. Bioorg Med Chem. 18, 8035-8043.

Liu, F., Yu, L.Q., Jiang, C., Yang, L., Wu, W.T., You, Q.D. 2010. Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. Bioorg Med Chem. 18, 4167-4177.

Jiang, C., You, Q., Liu, F., Wu, W., Guo, Q., Chern, J., Yang, L., Chen, M. 2009. Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors. Chem Pharm Bull. 57, 567-71.

楊蕾，江程，劉飛，尤啟冬，吳梧桐*。Eg5抑制劑體外高通量篩選。藥物生物技術。2008；15（6）：418－424。