北京化工大學化學與化工學院研究生導師介紹：郭新東

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郭新東，教授

Email:xdguo@buct.edu.cn

http://www.microneedlelab.com/

教育/工作經歷

2000-2004南京理工大學化工學院，學士

2004-2010華南理工大學化學與化工學院，博士

2007-2008新加坡生物工程與納米技術研究院，聯合培養博士生

2010-2013華南理工大學化學與化工學院，講師

2011-2013美國佐治亞理工學院（GeorgiaTech）化工程系、生物醫學工程系，博士后

2014-今北京化工大學材料學院，教授

研究領域

生物大分子高效遞送系統研究

高分子微針的設計與開發

生物材料結構與性能關系研究

研究成果及獲獎情況：

研究成果在Biomaterials, Macromolecules, Advanced Drug Delivery Reviews, Journal of Controlled Reslease, Soft Matter, AIChE Journal等重要學術刊物上發表學術論文50余篇，申請中國發明專利21項，美國發明專利3項。現主持國家自然科學基金、生物醫用材料北京實驗室項目、教育部博士點基金等多項基金。2012年獲全國優秀博士學位論文提名獎。

專著：

1. 章莉娟, 林文靜, 郭新東, 楊友強, pH響應聚合物膠束藥物遞送體系設計和構效關系, 科學出版社, 2018年6月。

2. Haripriya Kalluri, Seong-O Choi, Xin Dong Guo, Jeong Woo Lee, James Norman, Mark R. Prausnitz, Evaluation of Microneedles in Human Subjects, Book Chapter in <Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement> edited by Nina Dragicevic and Howard I. Maibach, Springer, 2017, 325-340.

代表性論文：

1. Xuan Jin, Dan Dan Zhu, Bo Zhi Chen, Mohammad Ashfaq, Xin Dong Guo*, Insulin Delivery Systems Combined with Microneedle Technology, Advanced Drug Delivery Reviews, 2018, 127: 119-137.

2. Bo Zhi Chen, Mohammad Ashfaq, Dan Dan Zhu, Xiao Peng Zhang, Xin Dong Guo*, Controlled delivery of insulin using rapidly separating microneedle patches fabricated from genipin-crosslinked Gelatin, Macromolecular Rapid Communication, 2018, 39(20): 1800075.

3. Jia Nan Zhang, Bo Zhi Chen, Mohammad Ashfaq, Xiao Peng Zhang, Xin Dong Guo*, Development of a BDDE-crosslinked hyaluronic acid based microneedles patch as a dermal fillers for anti-ageing treatment, Journal of Industrial and Engineering Chemistry, 2018, 65: 363-369.

4. Juan Li, Yuan Jun Ma, Yan Wang, Bo Zhi Chen, Xin Dong Guo*, Can Yang Zhang*, Dual redox/pH-responsive hybrid polymer-lipid composites: Synthesis, preparation, characterization and application in drug delivery with enhanced therapeutic efficacy, Chemical Engineering Journal, 2018, 341: 450-461.

5. Yang Chen, Bo Zhi Chen, Qi Lei Wang, Xuan Jin, Xin Dong Guo*, Fabrication of polymer coated microneedle patches for transdermal drug delivery, Journal of Controlled Release, 2017, 265: 14-21.

6. Dan Dan Zhu, Qi Lei Wang, Xu Bo Liu, Xin Dong Guo*, Rapidly Separating Microneedles for Transdermal Drug Delivery, Acta Biomaterialia, 2016, 41: 312-319.

7. Qi Lei Wang, Dan Dan Zhu, Xu Bo Liu, Bo Zhi Chen, Xin Dong Guo*, Microneedles with Controlled Bubble Sizes and Drug Distributions for Efficient Transdermal Drug Delivery, Scientific Reports, 2016, 6: 38755.

8. Yan Wang, Qiu Yu Li, Xu Bo Liu, Can Yang Zhang, Zhi Min Wu*, Xin Dong Guo*, Mesoscale simulations and experimental studies of pH-sensitive micelles for controlled drug delivery, ACS Applied Materials & Interfaces, 2015, 7(46): 25592-25600.

9. Shu Yu Nie, Wen Jing Lin, Na Yao, Xin Dong Guo*, Li Juan Zhang*, Drug Release from pH-Sensitive Polymeric Micelles with Different Drug Distributions: Insight from Coarse-Grained Simulations, ACS Applied Materials & Interfaces, 2014, 6(20): 17668-17678.

10. Xin Dong Guo, Nikken Wiradharma, Shao Qiong Liu, Li Juan Zhang, Majad Khan, Yu Qian, Yi-Yan Yang*, Oligomerized alpha-helical KALA peptides with pendant arms bearing cell-adhesion, DNA-binding and endosome-buffering domains as efficient gene transfection vectors, Biomaterials, 2012, 33(26): 6284-6291.

11. Xin Dong Guo, Li Juan Zhang, Zhi Min Wu, Yu Qian*, Dissipative Particle Dynamics Studies on Microstructure of pH-Sensitive Micelles for Sustained Drug Delivery, Macromolecules, 2010, 43(18): 7839-7844.

12. Xin Dong Guo, Li Juan Zhang, Yun Chen, Yu Qian*, Core/Shell pH-Sensitive Micelles Self-Assembled from Cholesterol Conjugated Oligopeptides for Anticancer Drug Delivery, AIChE Journal, 2010, 56(7): 1922-1931.

13. Xin Dong Guo, Jeremy Pang Kern Tan, Sung H. Kim, Li Juan Zhang, Ying Zhang, James L. Hedrick, Yi Yan Yang*, Yu Qian*, Computational studies on self-assembled paclitaxel structures: Templates for hierarchical block copolymer assemblies and sustained drug release, Biomaterials, 2009, 30(33): 6556-6563.

14. Xin Dong Guo, Fanny Tandiono, Nikken Wiradharma, Dingyue Knor, Chuan Guan Tan, Majad Khan, Yu Qian, Yi Yan Yang*, Cationic micelles self-assembled from cholesterol-conjugated oligopeptides as an efficient gene delivery vector, Biomaterials, 2008, 29(36): 4838-4846.

15. Xin Dong Guo, Li Juan Zhang, Yu Qian, Jian Zhou, Effect of composition on the formation of poly(DL-lactide) microspheres for drug delivery systems: Mesoscale simulations, Chemical Engineering Journal, 2007, 131(1-3): 195-201.