青島農業大學生殖科學研究院2017考研調劑信息

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青島農業大學生殖科學研究院招收碩士調劑生啦——本人是實驗室16級碩士，編輯此條信息招收碩士調劑生啦，此聯系方式為老師的聯系方式，要求專業方向與生物相關專業，總分在300分之上。調劑系統與3.17號晚上開啟，3.21面試，請有意向在生殖和發育相關方向發展的同學盡快聯系，聯系方式：程老師：13864805527，比個大心!!!歡迎歡迎——以下為沈偉教授簡介：-----

沈偉

性別:男

出生日期:1975-12-18

工作單位:動物科技學院生殖細胞生物學實驗室

研究方向:生殖細胞發生與生殖干細胞

研究課題項目名稱來源位次本人角色經費開始時間結束時間

利用精子介導基因轉移技術制備轉基因動物的研究國家自然科學基金1主持82009-07-012012-09-09

優質高產轉基因肉羊新品系培育國家重大專項1主持4342009-07-012010-12-12

卵母細胞與卵泡形成的調控機制國家科技部1主持134

胚胎干細胞體外分化的卵母細胞減數分裂的分子調控國家基金委1主持17

動物卵母細胞發生的分子調控山東省杰青1主持50

Dazl和Stra8基因調節卵母細胞發生及減數分裂啟動的分子機制國家基金1主持60

卵原細胞減數分裂啟動及卵母細胞生長起始調節機制科技部9731主持300

發表論文及著作題目年份位次刊名索引

Exposure to Brefeldin A promotes initiation of meiosis in murine female germ cells 2014 1 Reproduction, Fertility and Developmen SCI

Notch pathway regulates female germ cell meiosis progression and early oogenesis events in fetal mouse 2014 1 Cell Cycle SCI

Di-(2-ethylhexyl) phthalate and bisphenol A exposure impairs newborn mouse primordial follicle assembly in vitro 2014 1 Environmental and Molecular Mutagenesis SCI

Ovarian cell-like cells from skin stem cells restored estradiol production and estrus cycling in ovariectomized mice 2014 7 Stem Cells Dev SCI

Reconstitution of gametogenesis in vitro: meiosis is the biggest obstacle 2014 4 Journal of Genetics and Genomics, SCI

Transgenerational inheritance of ovarian development deficiency induced by maternal diethylhexyl phthalate exposure 2014 1 Reproduction, Fertility and Development SCI

Insulin regulates primordial follicle assembly in vitro by affecting germ cell apoptosis and elevating estrogen 2014 1 Reproduction, Fertility and Development SCI

Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse 2013 1 Environmental and Molecular Mutagenesis SCI

Deleted in Azoospermia-Like (DAZL) enhances in vitro-derived porcine germ cell formation and meiosis 2013 2 Stem Cells Dev SCI

Recovery of functional oocytes from cultured premeiotic germ cells after kidney capsule transplantation 2013 1 Stem Cells Dev SCI

Bisphenol A exposure modifies methylation of imprinted genes in mouse oocytes via the estrogen receptor signaling pathway 2012 1 Histochemistry and Cell Biology SCI

Fetal exposure to bisphenol A affects the primordial follicle formation by inhibiting the meiotic progression of oocyte 2012 1 Molcular Biology Report SCI

Midkine promotes proliferation of primordial germ cell by inhibiting the expression of the deleted in azoospermia-like gene 2012 1 Endocrionology SCI

A co-culture system with preantral follicular granulosa cells in vitro induces meiotic maturation of immature oocytes 2011 1 Histochemistry and Cell Biology SCI

Analysis of oocyte-like cells differentiated from porcine fetal skin-derived stem cell 2011 1 Stem Cell and Development, SCI

DNA methylation of germ cell-specific basic helix-loop-helix (HLH) of transcription factors, Sohlh2 and Figα, during germ cell development 2011 1 Mol Hum Reprod SCI

Murine folliculogenesis in vitro is stage-specifically regulated by insulin via the Akt signaling pathway 2010 1 Histochemistry and Cell Biology SCI

Effect of insulin on oogenesis from mouse fetal germ cells in a serum-free 3D culture system 2010 1 Reprod BioMed Online SCI

Maternal imprinting during mouse oocyte growth in vivo and in vitro 2009 1 Biochem Biophys Res Commun SCI

Pre-meiotic fetal mouse germ cells form typical oocyte-like cells but do not progress through meiosis in vitro 2009 1 Theriogenology SCI

Mature oocytes derived from purified mouse fetal germ cells 2008 5 Human Reproduction SCI

In vitro development of mouse fetal germ cells into mature oocytes 2007 1 Reproduction SCI

Targeting the exogenous htPAm gene on goat somatic cell beta- casein locus for transgenic goat production 2007 1 Molecular Reproduction and Development SCI

Serial nuclear transfer improves the developmental potential of mouse embryos cloned from oocytes matured in a protein-free medium 2007 5 Molecular Reproduction and Development SCI

Mouse oocytes derived from fetal germ cells are competent to support the development of embryos by in vitro fertilization 2006 1 Molecular Reproduction and Development SCI

Efficient and simple production of transgenic mice and rabbits using the new DMSO-sperm mediated exogenous DNA transfer method 2006 1 Molecular Reproduction and Development SCI

Human lactoferrin transgenic rabbits produced efficiently using DMSO-sperm mediated gene transfer. 2006 1 Reproduction, Fertility and Development SCI

Living offspring produced by mouse oocytes derived from premeiotic fetal germ cells 2006 1 Biology of Reproduction SCI

沈偉，博士，教授。1975年生，山東滕州市人。教育部新世紀優秀人才，山東省自然科學杰出青年基金獲得者，動物生殖與種質創新山東省高校重點實驗室負責人和首席專家，山東省“動物遺傳育種與繁殖”重點學科學術帶頭人，山東省優秀研究生導師、青島市優秀教師，生殖生物學會理事，動物遺傳標記學會理事，美國生殖生物學學會正式會員。Gene、PlosONE、Stem Cell Epigenetics等刊物編委，Development等30余種國際雜志審稿人。研究方向為生殖細胞發生與生殖干細胞，主要圍繞與動物繁殖潛能開發、人類生殖健康等相關問題，進行生殖干細胞和原始生殖細胞(PGC)的增殖與分化、卵母細胞發生的細胞互作與分子調節機制、動物生物技術育種等方面的研究。

2004年7月獲得了西北農林科技大學與軍事醫學科學院聯合培養博士學位，2006年6月北京大學細胞生物學博士后出站，2007年7月破格晉升為教授，2007年8月至2008年8月中國科技大學客座研究，2009年9月至2010年8月加拿大Guelph大學博士后。

近5年來，先后主持了國家重大科學研究計劃(973)“卵泡發育的分子調控”等項目的子課題4項，國家自然科學基金“胚胎干細胞體外分化的卵母細胞減數分裂的分子調控”等4項，國家轉基因生物新品種培育重點項目“優質高產轉基因肉羊新品系培育”2項，山東省自然科學杰出青年基金“動物卵母細胞發生的分子調控”1項，參加國家973項目、863重點項目、國家自然科學基金等課題10余項。

帶領的研究組建立了從減數分裂前的雌性生殖細胞向卵母細胞體外發生、發育的培養體系，使卵原細胞在體外順利完成了減數分裂的啟動，并成熟、受精后獲得發育的囊胚;利用該體系系統研究了卵母細胞發生的分子調節機制，以及印跡基因DNA甲基化建立和擦除的影響機制。建立了原始卵泡體外形成與發育的模型，并獲得了體外受精的囊胚;利用該模型，系統研究了卵泡形成與募集過程中PI3K/Akt信號通路的調節機制。近5年來，沈偉教授研究組在《Endocrinology》、《Cell Cycle》、《Stem Cell Dev》、《Histochem Cell Biol》、《Biol Reprod》、《Mol Hum Reprod》、《Reproduction》、《Biochem Biophys Res Commun》、《Reprod BioMed Online》、《Mol Reprod Dev》、《Reprod Fertil Dev》和《Theriogenology》等刊物上發表研究論文50余篇。已培養研究生22人，皆發表了SCI收錄論文，有研究生第一作者發表的論文累積影響因子達9.454，半數以上的研究生到了國內外重點大學和研究機構進行繼續深造。目前在讀碩士研究生11人、博士研究生4人。

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