中國藥科大學藥學院研究生導師介紹：周金培

導師信息來源：中國考研網 2016-07-08　相關院校：中國藥科大學

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周金培，博士，教授，博士生導師，1965.12出生，藥化教研室。1999年藥物化學博士研究生畢業后中國藥科大學藥化教研室從事藥物化學的教學與科研工作。2000年獲得中國藥學會藥物化學施維亞獎（Servier）。2001年評為副研究員，2010年評為教授。2005-2006年在日本岐阜藥科大學藥化室做訪問學者。

研究方向：抗腫瘤及心腦血管疾病新藥研究。課題研究：已負責完成科技部863博士基金一項；負責完成一項南京市回國人員資助項目。曾參加國家自然科學基金、國家新藥基金、“863”項目，醫藥局局控項目等縱向課題，在國家自然科學基金、新藥基金、江蘇省自然科學基金等基礎研究項目中，依據腫瘤、感染與炎癥性疾病、糖尿病等疾病復雜的發病機制和藥物的構效關系，進行新藥分子設計及合成，以尋找具有自主知識產權的新藥。已參與多項基金的評審，為國內外多家SCI雜志論文審稿專家。已申請專利14項，發表論文50余篇。

2003-2006主持國家高技術研究發展計劃(863計劃)兼有心血管作用的降糖藥物設計合成及活性研究，項目編號2003AA2Z3530。

2007-2008主持南京市回國人員基金“具有抗腫瘤活性的1，4取代哌啶類化合物的設計、合成與生物活性研究”

2011-2013參與江蘇省產學研聯合創新基金前瞻性聯合研究項目（BY2011158）

2009-2012參與國家自然科學基金項目“G004抗TXA2受體介導的心血管并發癥機制及受體作用模式”項目編號30973638

2009-2012參與國家重大專項“新型降血糖藥物G004的研究開發”。項目編號2009ZX09103-094

發表的主要論文：

1.Xueting Cai, Jie Yang , Jinpei Zhou, Wuguang Lu, Chunping Hua, Zhenhua Gu, Jiege Huo ,Xiaoning Wang, Peng Cao. Synthesis and biological evaluation of scopoletin derivatives. Bioorganic & Medicinal Chemistry, 21 (2013), 84-92.
2.Xiong Zhu, Jinpei Zhou*,, Yan Zhu, Xiaowen Hu, Yuemin Bian, Xinting Hu, Zhuo Tao, Cong Gao and Wenlong Huang. Synthesis and Biological Activities of Sulfinyl Acetamide Derivatives for Narcolepsy Treatment.Letters in Drug Design & Discovery, 2013, 10, 266-270
3.Wukun Liu, Jie Hua, Jinpei Zhou*, Huibin Zhang, Haiyang Zhu, Yanhua Cheng, Ronald Gust. Synthesis and in vitro antitumor activity of novel scopoletin derivatives. Bioorganic & Medicinal Chemistry Letters, 22 (2012), 5008-5012
4.Wukun Liu, Jinpei Zhou*, Tong Zhang, Huibin Zhang, Haiyang Zhu, Yanhua Cheng, Ronald Gust. Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine. Bioorganic & Medicinal Chemistry Letters, 22 (2012), 6076-6080.
5.Jinpei Zhou, Lei Wang, Lijuan Wei, Yu Zheng, Huibin Zhang , Yubin Wang, Peng Cao, Ao Niu, Jing Wang and Yue Dai. Synthesis and Antitumor Activity of Scopoletin Derivatives. Letters in Drug Design & Discovery, 2012, 9(4), 397-401
6.Wukun Liu, Jinpei Zhou*, Tong Zhang, Haiyang Zhu, Hai Qian, Huibin Zhang, Wenlong Huang,Ronald Gust. Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters, 2012, 22: 2701-2704
7.Wukun Liu, Jinpei Zhou#, Yu Zheng, Fan Qi, Huibin Zhang, Hai Qian, Jing Wang1,Yanhua Cheng and Ronald Gust. Design, Synthesis and Antiproliferative Activity of 2-Acetamidothiazole-5-carboxamide Derivatives. Medicinal Chemistry, 2012, 8, 587-594
8. Wukun Liu, Jinpei Zhou*, Fan Qi, Kerstin Bensdorf, Zhiyu Li, Huibin Zhang, Hai Qian,Wenlong Huang, Xueting Cai, Peng Cao, Anja Wellner, and Ronald Gust. Synthesis and Biological Activities of 2-Amino-thiazole-5-carboxylic Acid Phenylamide Derivatives. Arch. Pharm. Chem. Life Sci. 2011, 344, 451–458 451
9. Wukun Liu, Jinpei Zhou*, Kerstin Bensdorf , Huibin Zhang, Haoran Liu, YubinWang , Hai Qian,Yanchun Zhang, Anja Wellner, Gerhard Rubner, Wenlong Huang, Cancheng Guo, Ronald Gust. Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives. European Journal of Medicinal Chemistry, 2011, 46, 907-913
10.Wukun Liu, Jinpei Zhou*, Huibin Zhang, Hai Qian, Jiahan Yin, Kerstin Bensdorf and Ronald Gust. Synthesis and Biological Evaluation of Licofelone Derivatives as Anticancer and Anti-inflammatory Agents. Letters in Drug Design & Discovery, 2011, 8, 911-917
11.Jinpei Zhou, Hai Qian, Huibin Zhang, Hui Gao, Wenlong Huang, Xiaoyun Zhu, Shuaijian Ni, and Chuntao Zhang. Design, Synthesis and Biological Evaluation of Benzopyran Derivatives as KATP Channel Openers. Letters in Drug Design & Discovery, 2010, 7(6), 415-420
12.Jinpei Zhou, Shuaijian Ni, Huibin Zhang, Hai Qian, Yushi Chi, Wenlong Huang, Lu Yu, Xiaowen Hu and Wei Chen. Synthesis and Bioactivity Evaluation of Dipeptidyl Peptidase IV Resistant Glucagon-like Peptide-1 Analogues. Protein and Peptide Letter, 2010, 17(10), 1290-1295
13.Hai Qian, Wei Chen, Xiaoyan Zhang, Huibin Zhang, Jinpei Zhou*, Wenlong Huang, Jing Jin and Dongyan Dai.Synthesis and Biological Evaluation of Dihydroisoquinoline-2(1H)-Carbothioamide Derivatives as TRPV1 Antagonists. Letters in Drug Design & Discovery, 2010, 7(4): 235-237
14.Yanchun Zhang, Jinpei Zhou*, Weihong Pan, Xiaoming Wu, and Shuai Wang.Synthesis and Biological Study of 3-Butyl-1-(2,6-dichlorophenyl)-1H-[1,2,4]triazol-5(4H)-one Derivatives as Anti-hypertension Drugs. Letters in Drug Design & Discovery, 2010, 7(1): 18-22
15.Hai Qian, Wei Chen, Jin Pei Zhou*, Wen Long Huang, Hui Bin Zhang, Jing Jin. Total Synthesis of endothelin 1 by microwave-assisted solid phase method. Chinese Chemical Letters, 2010, 21:388-390
16.Hai Qian, Zhixian Fu, Huibin Zhang, Jinpei Zhou*, Wenlong Huang, Jing Jin, Wei Chen and Dongyan Dai.Synthesis and Biological Evaluation of Capsaicin Derivatives as Analgesia Drugs. Letters in Drug Design & Discovery, 2010, 7(2), 122-127
17.Jinpei Zhou, Xiaowen Hu, Huibin Zhang, Hai Qian, Wenlong Huang, Fan Qi and Yanchun Zhang. Synthesis and Biological Evaluation of 5,6-Dihydro-benzo[c] acridin-7-ol Derivatives as Anti-Alzheimer’s Disease Drugs. Letters in Drug Design & Discovery, 2009，6(8): 623-628
18.Jinpei Zhou, Huibin Zhang, Hai Qian, Liang Lin, Wenlong Huang and Shuaijian Ni. Synthesis and Biological Evaluation of Aromatase Inhibitors. Letters in Drug Design & Discovery, 2009，6(3): 181-185
19.ZHANG Hui-bin, ZHANG Ya-an, WU Guan-zhong, ZHOU Jin-pei*. HUANG Wen-long, HU Xiao-wen. Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents. Bioorganic & Medicinal Chemistry Letters, 2009，19（6）：1740-1744
20.Xiangyang Sha, Huibin Zhang, Wenlong Huang, Jinpei Zhou*, Yinghong Zhou. Design and Synthesis of Thiazolidinedione Derivatives as Selective PPARγ Modulators. Letters in Drug Design & Discovery, 2009，6(3): 224-227

申請專利：

1.周金培，魏麗娟，戴岳，張惠斌，蔣企洲.一種制備東莨菪素的新方法.申請號：200910029807.7,公開號：CN101519393A
2.周金培，張惠斌，黃文龍，吳斐華，劉武昆，錢海，程艷華.苯并[5,6]環庚基[1,2-b]吡啶衍生物、制備方法及其藥物組合物.申請號：201110153330.0,公開號：CN102260253A
3.周金培，張惠斌，華杰，劉武昆，程艷華.東莨菪素衍生物、制備方法及其用途申請號201210005398.9
4.周金培，張惠斌，華杰，劉武昆，程艷華.3-乙酰氨基-7-羥基-6-甲氧基香豆素衍生物、制備方法及其用途申請號201210005399.3
5.張惠斌，周金培，黃文龍，巫冠中.新的磺酰(硫)脲衍生物、其制備方法及含有它們的藥物組合物.專利號：CN1330630C
6.張惠斌,黃文龍,沙向陽,周映紅,周金培,錢海,張亞安.取代的四氫異喹啉衍生物、其制備方法及含有它們的藥物組合物.申請號：200810155076.6，公開號：CN101386617A

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