北京化工大學化學工程與技術專業(yè)研究生導師介紹：王艷東

Chen, W.-D., Yu, D., Forman, B.M., Huang, W and Wang, Y.-D*. The deficiency of G-protein-coupled bile acidreceptor gpbar1 (TGR5) enhances chemically-induced liver carcinogenesis. Hepatology. 2012, [Epub ahead of print].（國際肝病學排名第一的學術期刊，SCI一區(qū)，影響因子為11.665）
*通訊作者。

Wang, Y.-D.*, Chen, W.-D., Yu, D., Forman, B.M and Huang, W. The G-protein-coupledbile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatoryresponse through antagonizing nuclear factor κ light-chain enhancer ofactivated B cells (NF-κB) in mice. Hepatology. 2011, 54(4), 1421-1432. （國際肝病學排名第一的學術期刊，SCI一區(qū)，影響因子為11.665）
*通訊作者。

Chen, W.-D.*, Wang, Y.-D.*, Zhang, L., Shiah,S., Wang, M., Yang, F., Yu, D., Forman, B.M and Huang, W. Farnesoid X receptoralleviates age-related proliferation defects in regenerating mouse livers byactivating forkhead box m1b transcription. Hepatology. 2010, 51(3), 953-962.（國際肝病學排名第一的學術期刊，SCI一區(qū)，影響因子為11.665）
*同等貢獻第一作者

Chen, W.-D.*, Wang, Y.-D.*, Meng, Z., Zhang,L. and Huang, W. Nuclear bile acid receptor FXR in the hepatic regeneration. Biochimicaet Biophysica Acta-Molecular Basis of Disease. 2011, 1812(8), 888-892. （SCI一區(qū)，影響因子為5.387）
*同等貢獻第一作者

Wang, Y.-D., Chen, W.-D., Wang, M., Yu, D., Forman, B.M. andHuang, W.  Farnesoid X receptorantagonizes NF-κB in hepatic inflammatory response. Hepatology. 2008, 48(5), 1632-1643.（國際肝病學排名第一的學術期刊，SCI一區(qū)，影響因子為11.665）
ü該研究工作的重要意義被影響因子分別為11.68和11.67的國際學術期刊Gastroenterology（2009, 137(2), 734-735）和Hepatology（2008, 48(5), 1383-1386）專題報道和高度評價
üFaculty of 1000 Biology專題報道和高度評價，研究人員必讀重要論文

Wang, Y.-D., Chen, W.-D.and Huang, W. FXR: a metabolic regulator and a cell protector. CellResearch. 2008, 18(11),1087-1095.（SCI一區(qū)，影響因子為8.19）
üFaculty of 1000 Medicine專題報道和高度評價，推薦為研究人員需要閱讀和掌握的重要論文

Wang, Y.-D., Yang, F., Chen,W.-D., Huang, X., Lai, L., Forman,B.M. and Huang, W. Farnesoid x receptor protects liver cells from apoptosisinduced by serum deprivation in vitro and fasting in vivo. Molecular Endocrinology. 2008, 22(7), 1622-1632.（SCI一區(qū)，影響因子為4.54）
ü該研究工作被Endocrine News（2008, July, 13）專題報道

Wang, Y.-D., Chen, W.-D.and Huang, W. FXR, a target for different diseases. Histology and Histopathology. 2008, 23(5), 621-627.（SCI三區(qū)，影響因子為2.48）

Wang, Y.-D., Wu, J. andYuan, Y.-J. Salicylic acid-induced taxol production and isopentenylpyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei.CellBiology International. 2007, 31(10),1179-1183.（SCI四區(qū)，影響因子為1.48）

Wang, Y.-D., Yan, Y.-J. andWu, J. Induction studies of methyl jasmonate and salicylic acid on taxaneproduction in suspension cultures of Taxuschinensis var. mairei. BiochemicalEngineering Journal. 2004, 19(3), 259-265.（SCI一區(qū)，影響因子為2.645）

Wang, Y.-D., Yan, Y.-J. andWu, J. Translocation of isopentenyl pyrophosphate for Taxol biosynthesis insuspension cultures of Taxus chinensisvar. mairei. Plant Cell, Tissue and OrganCulture. 2003, 74, 283-288.（SCI一區(qū)，影響因子為3.09）

Wang, Y.-D., Yan, Y.-J.,Lu, M, Wu, J. and Jiang, J.-L. Inhibitor studies of isopentenyl pyrophosphatebiosynthesis in suspension cultures of the yew Taxus chinensis var. mairei.Biotechnologyand Applied Biochemistry. 2003,37 (1), 39-43.（SCI三區(qū)，影響因子為1.53）

Zhang, L., Wang,Y.-D., Chen, W.-D., Wang,X., Lou, G., Liu, N., Lin, M., Forman, B.M. and Huang, W. Promotion of liverregeneration/repair by farnesoid X receptor in both liver and intestine. Hepatology. 2012, [Epub ahead of print]（國際肝病學排名第一的學術期刊，SCI一區(qū)，影響因子為11.665）

Meng, Z., Wang, Y.-D., Wang, L., Jin, W.,Liu, N., Pan, H., Liu, L., Wagman, L., Forman, B.M and Huang, W. FXR regulatesliver repair after CCl4-induced toxic injury. Molecular Endocrinology. 2010, 24(5), 886-897. （SCI一區(qū)，影響因子為4.54）

Chen, W.-D.,Wang, Y.-D., Hu, H.-H. and Su, Z.-G. Hydrodynamics in an expanded bed of large size ion-exchangeresin, and natural product adsorption. Journal of Chemical Technology andBiotechnology. 2007, 82, 135–142.（SCI二區(qū)，影響因子為2.17）

Chen, W.-D., Wang,Y.-D.and Su, Z.-G. Suitability of stericmass-action model for ion-exchange equilibrium of micromolecule. Chinese Journal of Chemical Engineering. 2005, 13 (1), 17-22.（SCI三區(qū)，影響因子為0.83）

Chen, W.-D., Wang,Y.-D.,Zha L.-H., Ma, G.-H. and Su, Z.-G. Single-step recovery of ephedrinehydrochloride from raw materials using expanded bed adsorption. BiotechnologyLetters. 2004, 26,1233-1236.（SCI三區(qū)，影響因子為1.683）

Schoetz, U.,Cervelli, M., Wang, Y.-D.,Fiedler, P. and Buerstedde, J.-M. E2A expression stimulates Ighypermutation.Journal of Immunology. 2006,177(1), 395-400.（SCI一區(qū)，影響因子為5.79）

Chen, W.-D.,Hu, H.-H. and Wang, Y.-D.Analysis of steric mass-action model for protein adsorption equilibrium ontoporous anion-exchange adsorbent. Chemical Engineering Science. 2006, 61, 7068-7076.（SCI一區(qū)，影響因子為2.43）

Ge, Z., Yuan, Y.-J., Wang, Y.-D., Ma, Z. and Hu. Z.Ce4+-induced apoptosis of Taxus cuspidata cells in suspension cultures. Journalof Rare Earths. 2002, 20,139-144. （SCI三區(qū)，影響因子為0.9）

Chen, W.-D., Fu, X., Dong,B., Wang, Y.-D., Shiah, S., Moore,D.D and Huang, W. Neonatal activation of the nuclear receptor CAR results inepigenetic memory and permanent change of drug metabolism in mouse liver. Hepatology.2012, [Epub ahead of print].（國際肝病學排名第一的學術期刊，SCI一區(qū)，影響因子為11.665）

Meng, Z., Liu, N., Fu, X.,Wang, X., Wang, Y.-D., Chen, W.-D., Zhang, L., Forman, B.M andHuang, W. Insufficient bile acid signaling impairs liver repair in CYP27^-/-mice. Journal of Hepatology.2011, 55(4), 885-895. （SCI一區(qū)，影響因子為9.26）

Wahl, M.B., Caldwell, R.B., Kierzek, A.M., Arakawa1,H., Eyras, E., Hubner, N., Jung, C., Soeldenwagner, M., Cervelli1, M., Wang,Y.-D., Liebscher, V. and Buerstedde. J.-M. Evaluation of the chickentranscriptome by SAGE of B cells and the DT40 cell line. BMC Genomics. 2004, 5:98 (http://www.Biomedcentral.com/1471-2164/5/98) （SCI一區(qū)，影響因子為4.07）

王艷東, 元英進, 路明, 吳金川. Methyl jasmonate-induced cytochrome P-450monooxygenase in suspension cultures of Taxuschinensis var. mairei. 化工學報, 2002, 53 (增刊), 175-177.

王艷東, 路明, 元英進. 甲基茉莉酮酸對懸浮培養(yǎng)南方紅豆杉細胞代謝的影響. 中草藥, 2003, 34 (1), 27-30.

王艷東, 馬振毅, 元英進. 外源紫杉醇作用下南方紅豆杉細胞凋亡及動力學研究. 化學工程, 2002, 30 (5), 53-57.

王艷東, 葛志強, 馬振毅, 元英進. 外加紫杉醇后南方紅豆杉細胞的耐受性極其凋亡的研究. 高�；瘜W工程學報, 2002, 16 (4), 421-425.

王艷東, 路明, 元英進. 甲基茉莉酮酸對懸浮培養(yǎng)南方紅豆杉細胞生理態(tài)勢的影響. 精細與專用化學品, 2002(增刊), 616-620.

王艷東, 馬振毅, 元英進. 南方紅豆杉細胞懸浮培養(yǎng)過程中的分化現(xiàn)象研究. 無錫輕工大學學報, 1999, 18(5), 27-30.

路明, 王艷東, 許明麗, 元英進. 甲基茉莉酮酸對懸浮培養(yǎng)南方紅豆杉細胞自由基清除系統(tǒng)酶的影響. 中草藥, 2002, 33 (11), 985-988.

馬振毅, 王艷東, 元英進. 外加紫杉醇對懸浮培養(yǎng)東北紅豆杉細胞的誘導效應. 生物工程學報, 2002, 18 (2), 204-207.

元英進, 葛志強, 王艷東, 馬振毅, 胡宗定. 鈰誘導懸浮培養(yǎng)的東北紅豆杉細胞發(fā)生凋亡. 中國稀土學報, 2001, 19 (4), 357-361.

胡國武, 馬征, 王艷東, 元英進. 稀土對紅豆杉細胞中紫杉烯合成酶基因轉錄的影響. 中國稀土學報, 2000, 18 (4), 360-362.

Wang, Y.-D., Chen,W.-D. and Huang, W. Gastroenterology. 2009, 137(2), 736.（SCI一區(qū)，影響因子為11.68）

Wang,Y.-D., Chen, W.-D., Chen, X.-S. and Huang, W. “FXR” inthe book of “Nuclear Receptors ? Current Concepts and FutureChallenges” Series: Proteins and Cell Regulation (Editors: Bunce, Chris;Campbell, Moray J), Vol. 8, Springer, Netherlands, March. 2010, 307-326.

Wang,Y.-D. and Caldwell R.B. “Isolation of nuclear and cytoplasmicproteins from DT40 cells” in the book of “Reviews and Protocols in DT40Research ? Subcellular Biochemistry” (Editors: Buerstedde, J.-M. and Takeda,S.), Vol. 40, Springer, New York, 2006, 439-440.

王艷東, 葛志強, 元英進. 第八章“紫杉醇和多烯紫杉醇的臨床前研究”, in: 抗癌藥物紫杉醇和多烯紫杉醇 （主編，元英進）化學工業(yè)出版社, 2002年11月.

王艷東, 葛志強, 元英進. 第九章“紫杉醇和多烯紫杉醇臨床研究”, in: 抗癌藥物紫杉醇和多烯紫杉醇 （主編，元英進）化學工業(yè)出版社, 2002年11月.

李景川, 王艷東, 元英進. 第六章“紫杉醇的生物合成”, in: 抗癌藥物紫杉醇和多烯紫杉醇（主編，元英進）化學工業(yè)出版社, 2002年11月.

元英進, 王艷東. 第一章“概述”, in: 植物細胞培養(yǎng)工程（主編，元英進）化學工業(yè)出版社, 2004年.

TGR5 signaling protects against inflammatory bowel diseasesthrough antagonizing NF-κB signaling and reactive oxygen species generation. Digestive Disease Week, 2012, SanDiego, California, USA

Farnesoid X receptor alleviates age-relatedproliferation defects in regenerating mouse livers. Keystone meeting; Nuclear Receptors: Development, Physiology andDisease, 2010, Colorado, USA

FXR suppresses JNK signaling preventing liver fromtumorignensis. The Meeting of LA areaReceptor labs, April 24, 2009, Duarte, California, USA

Novel roles of FXR in hepatic inflammation andhepatocarcinogenesis. Keystone meeting;orphan receptor, 2008, Whistler, British Columbia, Canada

FXR regulates liver repair after CCl4-inducedinjury. Nuclear receptors: bench tobedside, 2008, Cold Spring Harbor Laboratory, New York, USA

Bile acids induce the expression of the Foxm1b genevia activation of the Farnesoid X receptor contributing to aged mice liverregeneration. 28^th Annual Advanceof the Research Staff Organization of City of Hope, 2008, Lake Arrowhead,California, USA

FXR plays a protective role in HepG2 cell apoptosisinduced by serum deprivation. TheMeeting of LA area Receptor labs, April 20, 2007, Duarte, California, USA

Differentiation in Taxuschinensis var. mairei cell suspension cultures. APBIO'99 meeting,1999, Hong Kong, China

Wang, Y.-D., Chen,W.-D., Yu, D., Forman,B.M., Huang, W. TGR5 signaling protects againstinflammatory bowel diseases through antagonizing NF-κB signaling and reactive oxygen species generation.Gastroenterology.2012 (Suppl.1), 142(5), s-863.（SCI一區(qū)，影響因子為11.68）