中國藥科大學藥學院研究生導師介紹：馮芳

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馮芳,藥物分析學博士，教授、博士生導師；教育部藥物質量與安全預警重點實驗室學術帶頭人。2000－2001年日本歧阜藥科大學藥學部高級訪問學者。

研究方向藥物質量研究與評價

研究內容藥物質量分析方法建立研究、藥物體內過程分析研究、手性藥物拆分及體內立體選擇性藥代動力學研究、中藥（復方）藥效物質基礎研究。

學術兼職國家藥典委員會委員、國家獸藥典委員會委員、國家藥監局保健食品安全和技術規范專家委員會委員；國家科學技術獎勵評審專家；國家藥監局保健食品、化妝品、獸藥評審專家；國家科技專家庫在庫專家；教育部高校同行評議專家；江蘇省新藥及保健食品審評專家。《藥物分析雜志》、《中國藥科大學學報》編委。

人才計劃及主要榮譽江蘇省“333高層次人才培養工程”首批中青年科學技術帶頭人；青藍工程江蘇省中青年學術帶頭人；“十五”國家級重點教材《藥物分析》編委、省一類精品課程主要成員；《有機光譜分析》（副主編）獲國家醫藥管理局科技進步三等獎；江蘇省優秀研究生課程《藥物光譜分析選論》負責人；2007、2009、2010年江蘇省優秀研究生論文導師，2010年、2012年圣和研究生創新成果二等獎導師。

近年來科研工作：

1．國家自然科學基金項目負責人。

2．江蘇省科技廳科技支撐計劃項目負責人。

3．科技部重大新藥創制項目子課題負責人。

4．企業委托新藥質量研究、體內過程分析研究、代謝產物分析研究等項目負責人。

近年來代表性論文、論著：

1.An untargeted metabolomics-driven approach based on LC–TOF/MS and LC–MS/MS for the screening of xenobiotics and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma. Journal of Pharmaceutical and Biomedical Analysis. 2015,115: 315–322 .

2.An effective integrated method for comprehensive identification of eighty-five compounds in Zhi-Zi-Da-Huang decoction by HPLC-DAD-ESI-MS (TOF) and HPLC-DAD-ESI-MS/MS (QqQ) without the help of reference standards. Analytical method. 2014, 6:4312-4327.

3.Network Pharmacology-Based Antioxidant Effect Study of Zhi-Zi-Da-Huang Decoction for Alcoholic Liver Disease. Evidence-Based Complementary and Alternative Medicine. 2015, 1- 6.

4.Optimization of the separation and determination of nitidine and chelerythrine in zanthoxylum nitidum by high-performance liquid chromatography with fluorescence detection. J Chromatogr Sci. 2014 , 52(2):164-168.

5.Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: restoration of monoamine neurotransmitters in discrete brain regions. Pharm Biol. 2013, 51(2):213-20.

6.A  highly sensitive nonenzymatic glucose sensor based on CuO nanowires. Microchim Acta. 2012, 176:411-417.

7.Pharmacokinetics of Geniposide in Zhi-Zi-Hou-Pu Decoction and in Different Combinations of its Constituent Herbs. Phytotherapy Research. 2012, 26: 67-72

8.Pyrosequencing on nicked dsDNA generated by nicking endonucleases. Analytical Chemistry. 2010, 82(5):2074-81.

9.Determination of selected elements in aqueous extractions of a traditional Chinese medicine formula by ICP-MS and FAAS: evaluation of formula rationality. Analytical Letters, 2010, 43: 983-992.

10.Identification of components in Zhi-Zi-Da-Huang decoction by HPLC coupled with electrospray ionization tandem mass spectrometry, photodiode and fluorescence detectors. Journal of Pharmaceutical and Biomedical Analysis,.2009, 49, 1157-1165.

11.Evaluation of hepatoprotective effect of Zhi-Zi-Da-Huang decoction and its two fractions against acute alcohol-induced liver injury in rats. Journal of Ethnophamacology. 2009, 126, 273-279.

12.Influences of urinary pH on the pharmacokinetics of three amphetamine-type stimulants using a new high-performance liquid chromatographic method. Journal of Pharmaceutical Science. 2009, 98(2):728-38.

13.Development of a new pre-derivatization LC method for analysis of branched-chain and aromatic amino acids in rat plasma and to monitor their dynamic variation as a result of acute hepatic injury. Chromatographia, 2009, 70, 57-65.

14.主編《藥物分析》，東南大學出版社，2011年。

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