中國藥科大學(xué)中藥學(xué)院研究生導(dǎo)師介紹：楊蕾

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楊蕾，女，博士，1980年5月生，中國藥科大學(xué)天然藥物化學(xué)教研室副教授。主要承擔(dān)本科生天然藥物化學(xué)課程、研究生天然物結(jié)構(gòu)化學(xué)課程的教學(xué)工作。2003年中國藥科大學(xué)生物技術(shù)專業(yè)本科畢業(yè)。2008年中國藥科大學(xué)微生物與生化藥學(xué)博士畢業(yè)，導(dǎo)師吳梧桐教授。2011年中國藥科大學(xué)中藥學(xué)院博士后出站，導(dǎo)師孔令義教授。主要研究方向為天然產(chǎn)物的高通量藥物篩選體系的建立、中藥及天然藥物的活性成分和機(jī)制研究、基于生物酶反應(yīng)的生物轉(zhuǎn)化研究。具體內(nèi)容包括抗腫瘤藥物的篩選和機(jī)制研究、逆轉(zhuǎn)腫瘤多藥耐藥性的藥物篩選和機(jī)制研究等。

聯(lián)系方式：Tel：025-83271402,Email：dorothy19802003@163.com

通信地址：南京市童家巷24號，中國藥科大學(xué)天然藥物化學(xué)教研室，郵編210009。

主持的科研項目:

中國藥科大學(xué)引進(jìn)人才基金

2011-2012中央高校基本科研業(yè)務(wù)費(fèi)培育項目（P-gp高表達(dá)骨肉瘤多藥耐藥細(xì)胞模型的建立及中藥中相關(guān)新型逆轉(zhuǎn)劑的篩選，項目批準(zhǔn)號：JKP2011014，8萬）

2013-2015國家自然科學(xué)基金（逆轉(zhuǎn)P-gp介導(dǎo)的骨肉瘤細(xì)胞多藥耐藥性作用中藥的篩選及其機(jī)制研究，項目批準(zhǔn)號：81202901，22萬）

近期代表性論文：

Geng, Y.D., Yang, L. (Co-first author), Zhang, C., Kong, L.Y. 2014. Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells. Food Chem. Toxicol. 73. 7-16.

Hu, S.M., Luo, J., Yang, L. (co-corresponding author), Kong, L.Y. 2014.Exploration of possible biosynthetic origin of 1/8/9-orthoester moiety in phragmalins. Tetrahedron Letters. 55, 815-817.

Wu, L., Luo, J., Zhang, Y., Wang, X., Yang, L. (co-corresponding author), Kong, L.Y. 2014. Cassane-type diterpenoids from the seed kernels of Caesalpinia bonduc. Fitoterapia. 93, 201-208.

Zhang, C., Yang, L., Wang, X.B., Wang, J.S., Geng, Y.D., Yang, C.S., Kong, L.Y. 2013. Calyxin Y induces hydrogen peroxide-dependent autophagy and apoptosis via JNK activation in human non-small cell lung cancer NCI-H460 cells. Cancer Lett. 340, 51-62.

Guo, C., Wang, J.S., Zhang, Y., Yang, L., Wang, P.R., Kong L.Y. 2012. Relationship of chemical structure to in vitro anti-inflammatory activity of tirucallane triterpenoids from the stem barks of Aphanamixis grandifolia. Chem Pharm Bull. 60, 1003-1010.

Yang, L., Wei, D.D., Chen, Z., Wang, J.S., Kong, L.Y. 2011. Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum. Phytomedicine. 18, 710-718.

Yang, L., Wei, D.D, Chen, Z., Wang, J.S., Kong, L.Y. 2011. Reversal effects of traditional Chinese herbs on multidrug resistance in cancer cells. Nat Prod Res. 25, 1885-1889.

Yang, L., Jiang, C., Liu, F., You, Q.D., Wu, W.T. 2008. Cloning, enzyme characterization of recombinant human Eg5 and the development of a new inhibitor. Biol Pharm Bull. 31, 1397-1402.

Jiang, C., Yang, L. (Co-first author), Wu, W.T., Guo, Q.L., You, Q.D. 2011. CPUYJ039, a newly synthesized benzimidazole-based compound, is proved to be a novel inducer of apoptosis in HCT116 cells with potent KSP inhibitory activity. J Pharm Pharmacol. 63, 1462-1469.

Jiang, C., Yang, L., Wu, W.T., Guo, Q.L., You, Q.D. 2011. De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin-4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors. Bioorg Med Chem. 19, 5612-5627.

Fu, R.G., You, Q.D., Yang, L., Wu, W.T., Jiang, C., Xu, X.L. 2010. Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents. Bioorg Med Chem. 18, 8035-8043.

Liu, F., Yu, L.Q., Jiang, C., Yang, L., Wu, W.T., You, Q.D. 2010. Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. Bioorg Med Chem. 18, 4167-4177.

Jiang, C., You, Q., Liu, F., Wu, W., Guo, Q., Chern, J., Yang, L., Chen, M. 2009. Design, synthesis and evaluation of tetrahydroisoquinolines as new kinesin spindle protein inhibitors. Chem Pharm Bull. 57, 567-71.

楊蕾，江程，劉飛，尤啟冬，吳梧桐*。Eg5抑制劑體外高通量篩選。藥物生物技術(shù)。2008；15（6）：418－424。