北京科技大學化生學院生物工程與傳感技術研究中心研究生導師：董海峰

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董海峰

北京科技大學教授/博導，生物工程與傳感技術研究中心副主任

辦公地點：化生樓306

辦公電話：010-82376576

電子郵件：hfdong@ustb.edu.cn

科研方向：生物傳感，藥物運輸，納米藥物

社會職務：中國生物檢測檢測聯盟理事; 中國自由基生物學與自由基醫學專業委員會青年委員 中國醫學生物技術協會生物診斷分會“生物診斷新技術與新材料”委員

簡歷

2005年與2008年分別獲得三峽大學學士和重慶大學碩士學位。2011年獲南京大學分析化學獲博士學位(導師：鞠熀先教授)，匹茲堡大學博士后(2012.10-2013.9)，京都大學高級訪問教授(2015，7-10)。北京科技大學師資博士后(2011.7-2013.9，合作導師，張學記)，北京科技大學生物傳感中心特聘教授(2013.10-2014.07)，北京科技大學教授、博導(2014.8-至今)。

科研業績

2010年以來，在Chem. Rev., Angew. Chem., ACS Nano, Adv. Funct. Mater., Chem. Sci. Anal. Chem.等雜志發表SCI論文65篇，IF論文被包括Nature Chem., Chem. Rev., Angew. Chem. In. Ed等雜志引用2500余次。現為RSC advances Panel Reviewer，《分析儀器》編委。出版中英文專著各一本。 代表性基金： 1. 國家自然基金面上項目“二維過渡金屬碳化物/氮化物納米探針核酸標志物分析” 21874008， 2019-01-01至2022-12-31 , 64 萬 2. 國家重點研發計劃“數字診療裝備研發” 專項，2016YFC0106602， “芯片-質譜創新技術平臺對循環腫瘤核酸標志物的擴增放大與定量分析在臨床應用中的方案” 2016/01-2018/12，212萬，子課題負責人 3. 北京食品營養與人類健康高精尖創新中心開放課題，20171002，“食品安全檢測及分析方法研究”2017/08-2019/07，30萬，主持 4. 國家自然科學基金應急項目，21645005，“乳腺癌“液相組織切片”循環腫瘤DNA的檢測新方法研究”2017/01-2017/12，10 萬 已結題，主持 5. 國家自然基金-青年基金，21305008，新型多功能貴金屬納米探針與microRNA高效檢測新方法的研究，2014/01-2016/12，25，萬已結題，主持 6. 中國博士后基金特別資助，2012T50042，腫瘤細胞內MicroRNA成像分析，2013/01-2014/12，15萬，已結題，主持

獲得獎勵/專利

曾獲2012年江蘇省百篇優秀博士論文、2013年全國百篇優秀博士學位論文提名、2013年教育部自然科學一等獎，2014，2018年中國分析測試協會科技一等獎。 專利： 1.一種基于硫化銅的熱消融作用介導的經皮給藥的方法，發明專利，董海峰，王冬冬，盧惠婷，201810195852 .9 2.利用瓊脂糖凝膠電泳可視化檢測多種miRNAs的方法，發明專利，董海峰，代文浩，201810351048 .5 3. 一種單層熒光納米二硫化鉬的制備方法 201410574973.6，2014.10.23

招生計劃

每年招收1-2名博士研究生，3名碩士研究生

代表性論文論著

專著：

1. 鞠熀先, 董海峰, 張學記, 核酸檢測：DNA與microRNA檢測方法, 知識產權出版社, 242千字，2015

2. Xueji Zhang, Haifeng Dong, Yaping Tian. MicroRNA detection and Pathological Function, Springer，37.4 千字，2015

代表性論文

1. Fan Yang, Yaru Cheng, Yu Cao, Haifeng Dong*ab, Huiting Lu, Kai Zhang, Xiangdan Meng, Conghui Liu, and Xueji Zhang* bSensitively Distinguish Intracellular Precursor and Mature MicroRNA Abundance.Chemical Science,

SC-EDG-07-2018-003305.R1 accepted

2. Huiting Lu, Fan Yang, Benhan Liu, Kai Zhang, Yu Cao,Wenhao Dai, Wenjun Li* and Haifeng Dong.* Intracellular low-abundance microRNA imaging by a NIR-assisted entropy-driven DNA system. Nanoscale Horizons. 2018, DOI: 10.1039/C8NH00330K, in press

3. Kai Zhang, Yuedong Zhang, Xiangdan Meng, Huiting Lu, Huan Chang,Haifeng Dong,* Xueji Zhang* Biomaterials, 2018, 185, 301-309

4. Kai Zhang, Xiangdan Meng, Yu Cao, Zhou Yang,* Haifeng Dong,* Yuedong Zhang, Huiting Lu, Zhuojie Shi, and Xueji Zhang Metal-Organic Framework Nanoshuttle for Synergistic Photodynamic and Low-Temperature Photothermal Therapy. Advanced Functional Materials. 2018, 28, 1804634

5. Conghui Liu, Chao Chen, Shuzhou Li, Haifeng Dong,* Wenhao Dai, Tailin Xu, Yang Liu, Fan Yang and Xueji Zhang. Analytical Chemistry, 2018, 90, 10591-10599.

6. Xiangdan Meng, Kai Zhang, Wenhao Dai, Yu Cao, Fan Yang, Haifeng Dong * and Xueji Zhang* Multiplex microRNA imaging in living cells using DNA-capped-Au assembled hydrogels. Chemical Science 2018, 9, 7419-7425

7. Dongdong Wang, Haifeng Dong *, Meng Li, Yu Cao, Fan Yang, Kai Zhang, Wenhao Dai, Changtao Wang, Xueji Zhang * Erythrocyte−cancer hybrid membrane camouflaged hollow copper sulfide nanoparticles for prolonged circulation life and homotypic-targeting photothermal/ chemotherapy of melanoma. ACS Nano, 2018, 12 (6), 5241-5252

8. Wenhao Dai, Jing Zhang, Xiangdan Meng, Jie He, Kai Zhang, Yu Cao, Dongdong Wang, Haifeng Dong,* Xueji Zhang * Catalytic hairpin assembly gel assay for multiple and sensitive microRNA detection.Theranostics, 2018, 8(10), 2646-2656.

9. Yu Cao, Haifeng Dong , Shaotao Pu, and Xueji Zhang  Photoluminescent two-dimensional SiC quantum dotsfor cellular imaging and transport.

Nano Research 2018,11(8), 4074-4081

10. Yu Cao, Shuzhou Li, Chao Chen, Dongdong Wang, Tingting Wu, Haifeng Dong, * Xuej Zhang,*

Rattle-type Au@Cu2−xS hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy.

Biomaterials. 2018, 158, 23-33.

11. Xiangdan Meng, Wenhao Dai, Kai Zhang, Haifeng Dong* and Xueji Zhang.*

Imaging Multiple MicroRNAs in Living Cell by ATP Self-Powered Strand-Displacement Cascade Amplification.

Chemical Science, 2018,

9, 1184 -1190

12. Wenhao Dai, Haifeng Dong,* Keke Guo and Xueji Zhang.*

Near-Infrared Triggered Strand Displacement Amplification for MicroRNA Quantitative Detection in Single Living Cell.

Chemical Science,

2018, 9, 1753 - 1759

13. Xiangdan Meng, Zhiqiang Liu, Yu Cao, Wenhao Dai, Kai Zhang, Haifeng Dong*, Xiaoyan Feng* and Xueji Zhang*.

Fabricating Aptamer-Conjugated Pegylated-MoS2/Cu1.8S Theranostic Nanoplatform for Multiplexed Imaging Diagnosis and Chemo-Photothermal Therapy of Cancer.

Advanced Functional Materials 2017，27，1605592.

14. Kai Zhang, HaiFeng Dong,*

Wenhao Dai. Xiangdan Meng, Huiting Lu, Tingting Wu and Xueji Zhang*.

Fabricating Pt/Sn-In2O3 Nanoflower with Advanced Oxygen Reduction Reaction Performance for High-Sensitivity MicroRNA Electrochemical Detection. Analytical Chemistry 2017, 89(1), 648-655.

15. Wenhao Dai, Haifeng Dong*, Bunshi Fugetsu, Yu cao, Huiting Lu, Xinlei Ma and Xueji Zhang*.

Tunable Fabrication of Molybdenum Disulfide Quantum Dots for Intracellular MicroRNA Detection and Multiphoton Bioimaging. Small 2015, 11(33), 4158-4164.

16. Haifeng Dong, Xiangdan Meng, Wenhao Dai, Yu Cao, Huiting Lu, Shu-Feng Zhou and Xueji Zhang*.

Highly Sensitive and Selective MicroRNA Detection Based on DNA-Bio-Bar-Code and Enzyme-Assisted Strand Cycle Exponential Signal Amplification. Analytical Chemistry 2015, 87(8), 4334-4340.

17. Haifeng Dong, Jianping Lei, Lin Ding, Yongqiang Wen, Huangxian Ju* and Xueji Zhang*. MicroRNA: Function, Detection, and Bioanalysis. Chemical Reviews 2013, 113(8), 6207-6233.

18. Haifeng Dong, Shi Jin, Huangxian Ju, Kaihong Hao, Li-Ping Xu, Huiting Lu, and Xueji Zhang*. Trace and Label-Free MicroRNA Detection Using Oligonucleotide Encapsulated Silver Nanoclusters as Probes. Analytical Chemistry 2012, 84(20), 8670-8674.

19. Haifeng Dong, Jing Zhang, Huangxian Ju*, Huiting Lu, Shiyan Wang, Shi Jin, Kaihong Hao, Hongwu Du and Xueji Zhang*. Highly Sensitive Multiple microRNA Detection Based on Fluorescence Quenching of Graphene Oxide and Isothermal Strand-Displacement Polymerase Reaction. Analytical Chemistry 2012, 84(10), 4587-4593.

20. Haifeng Dong, Jianping Lei, Huangxian Ju*, Huiting Lu, Shiyan Wang, Wenjie Guo, Zhu Zhu and Feng Yan*. Target-Cell-Specific Delivery, Imaging, and Detection of Intracellular MicroRNA with a Multifunctional SnO2 Nanoprobe. Angewandte Chemie International Edition 2012, 124(19), 4685-4690.

21. Haifeng Dong, Lin Ding, Feng Yan*, Hanxu Ji and Huangxian Ju*. The Use of PolyethylenimineCGrafted Graphene Nanoribbon for Cellular Delivery of Locked Nucleic Acid Modified Molecular Beacon for Recognition of MicroRNA. Biomaterials 2011, 32(15), 3875-3882.

22. Haifeng Dong, Feng Yan*, Hanxu Ji, Danny K. Y. Wong* and Huangxian Ju*. Quantum-Dot-Functionalized Poly(styrene-co-acrylic acid) Microbeads: Step-Wise Self-Assembly, Characterization, and Applications for Sub-femtomolar Electrochemical Detection of DNA Hybridization. Advanced Functional Materials 2010, 20(7), 1173-1179.

23. Haifeng Dong, Wenchao Gao, Feng Yan*, Hanxu Ji and Huangxian Ju*. Fluorescence Resonance Energy Transfer between Quantum Dots and Graphene Oxide for Sensing Biomolecules. Analytical Chemistry 2010,82(13), 5511-5517.