華中農業大學信息學院生物信息研究生導師：宋永健

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姓名：宋永健

性別：男

職稱：講座教授

學位：博士

電話：（65）68088039

郵箱：sungk@gis.a-star.edu.sg

工作單位：

華中農業大學信息學院

研究方向：

壓縮索引數據結構；二代測序數據ChIP-seq以及ChIA-PET數據分析；基于DNA以及組蛋白進行motif的查找；系統進化樹以及系統網絡分析

教育經歷：

1990.09-1993.08, 香港大學, 計算機學院, 學士學位

1993.09-1998.08, 香港大學, 計算機學院, 碩士學位

主要職歷：

2000.12－2001.10 香港大學，電子商務研究所 高級技術總監

2001.11－2007.06 新加坡國立大學計算學院 副教授

2003－至今 新加坡基因組研究所 高級組長

2007.07－2014.12 新加坡國立大學計算機學院 副教授

2015－至今 新加坡國立大學計算機學院 教授

科研成果:

根據谷歌學術統計，H-index為43，在知名雜志（SODA，Bioinformatics，Cell，Nature，Nature Genetics，Nature Medicine，NatureMethods，Genome Research，Genome Biology等）總共發表235篇研究論文，其中最近幾年主要期刊論文如下

1.Lim, J.Q., Tennakoon, C., Guan, P. and Sung, W.K. (2015) BatAlign: an incremental method for accurate alignment of sequencing reads. Nucleic acids research, 43, e107.

2, Guan, P. and Sung, W.K. (2016) Structural variation detection using next-generation sequencing data: A comparative technical review. Methods.

3, Jansson J, Choy C, Sadakane K, Ken Wing Kin SUNG (In Press) "Computing the Maximum Agreement of Phylogenetic Networks" Theoretical Computer Science, to appear

4, Jansson J, Ng Joseph HK, Sadakane K, Ken Wing Kin SUNG (In Press) "Rooted Maximum Agreement Supertrees"Algorithmica, to appear

5, Tie-Fei Liu, Yi Li, Jianjun LIU, Ankush Mittal, Pei-Lin Mao, Ken Wing Kin SUNG (In Press) "Effective Algorithms for TagSNP Selection" Journal of Bioinformatics and Computational Biology, to appear

6, Leong HW, Preparata FP, Willy H, Ken Wing Kin SUNG (In Press) "On the control of hybridization noise in DNA Sequencing-by-Hybridization" Journal of Bioinformatics and Computational Biology, to appear

7, Yingren Liu, Radha Krishna Murthy KARUTURI, Ken Wing Kin SUNG (In Press) "Cell-cycle Regulated Promoter Motif Prediction using Time-course" Micro Data, to appear in the proc of IEEE Symposium on Bioinformatics & Bioengineering (BIBE05), Minneapolis, Minnesota, October, 2005

8, Tennakoon C, Purbojati RW, Sung WK "BatMis: A fast algorithm for k-mismatch mapping." Bioinformatics 2012 Jun 10

9, Hassanzadeh R, Eslahchi C, Sung WK "Constructing phylogenetic supernetworks based on simulated annealing." Mol Phylogenet Evol 2012 Jun ; 63(3) : 738-44 Epub 2012 Mar 3

10, Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M "Target gene analysis by micros and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors."PLoS Genet 2012 May ; 8(5) : e1002728 Epub 2012 May 17

11, Li G, Ruan X, Auerbach RK, Sandhu KS, Zheng M, Wang P, Poh HM, Goh Y, Lim J, Zhang J, Sim HS, Peh SQ, Mulawadi FH, Ong CT, Orlov YL, Hong S, Zhang Z, Landt S, Raha D, Euskirchen G, Wei CL, Ge W, Wang H, Davis C, Fisher-Aylor KI, Mortazavi A, Gerstein M, Gingeras T, Wold B, Sun Y, Fullwood MJ, Cheung E, Liu E, Sung WK, Snyder M, Ruan Y "Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation." Cell 2012 Jan 20 ; 148(1-2) : 84-98

12, Ng KP, Hillmer AM, Chuah CT, Juan WC, Ko TK, Teo AS, Ariyaratne PN, Takahashi N, Sawada K, Fei Y, Soh S, Lee WH, Huang JW, Allen JC, Woo XY, Nagarajan N, Kumar V, Thalamuthu A, Poh WT, Ang AL, Mya HT, How GF, Yang LY, Koh LP, Chowbay B, Chang CT, Nadarajan VS, Chng WJ, Than H, Lim LC, Goh YT, Zhang S, Poh D, Tan P, Seet JE, Ang MK, Chau NM, Ng QS, Tan DS, Soda M, Isobe K, Nöthen MM, Wong TY, Shahab A, Ruan X, Cacheux-Rataboul V, Sung WK, Tan EH, Yatabe Y, Mano H, Soo RA, Chin TM, Lim WT, Ruan Y, Ong ST "A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer." Nat Med 2012 Apr ; 18(4) : 521-8 Epub 2012 Mar 18

13, Sung WK, Zheng H, Li S, Chen R, Liu X, Li Y, Lee NP, Lee WH, Ariyaratne PN, Tennakoon C, Mulawadi FH, Wong KF, Liu AM, Poon RT, Fan ST, Chan KL, Gong Z, Hu Y, Lin Z, Wang G, Zhang Q, Barber TD, Chou WC, Aggarwal A, Hao K, Zhou W, Zhang C, Hardwick J, Buser C, Xu J, Kan Z, Dai H, Mao M, Reinhard C, Wang J, Luk JM "Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma." Nat Genet 2012 ; 44(7) : 765-9 Epub 2012 May 27

14, Tan PY, Chang CW, Chng KR, Wansa KD, Sung WK, Cheung E "Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival." Mol Cell Biol 2012 Jan ; 32(2) : 399-414 Epub 2011 Nov 14

15, Xu H, Sung WK "Identifying differential histone modification sites from ChIP-seq data." Methods Mol Biol 2012 ; 802 : 293-303

科研獎項：

1，青年科研獎 （新加坡國立大學最高科研獎），2008

2，DREAM2挑戰賽冠軍，2008

3，國家科學獎（新加坡最高科學獎），2006

4，FIT最佳論文獎，2003，日本

出版書籍：

“Algorithms in Bioinformatics : A Practical Introduction”, CRC Press (Taylor & Francis Group), 24 Nov 2009.

Book website: http://www.comp.nus.edu.sg/~ksung/algo_in_bioinfo/