河北大學化學與環境科學學院研究生導師：成永強

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河北大學化學與環境科學學院劉保生研究生導師成永強介紹如下：

成永強，男，河北省定州市人，河北大學博士，教授，博士研究生導師。

研究方向：生化分析與生物傳感。研究工作發表在Angew. Chem. Int. Ed., Anal. Chem., Chem. Commun., ACS Appl. Mater. Interfaces, Analyst等期刊上。
獲2012年教育部全國優秀博士學位論文提名獎；獲2012年河北省優秀博士學位論文；獲2010年河北省自然科學獎一等獎（2010ZR1002-3）；2017年河北省自然科學獎二等獎（2017ZR2001-2）。

聯系方式：E-mail：yqcheng@hbu.edu.cn； yqcheng@126.com

一、主講課程：儀器分析、儀器分析實驗、分子光譜分析

二、研究內容：

1、核酸和蛋白質等生物大分子檢測新方法新技術研究；

2、細胞、細菌識別、成像及殺傷新材料新方法研究。

三、主持科研項目

1. 國家自然科學基金(21475031)，DNA水凝膠-陽離子共軛聚合物雜化熒光納米粒子的制備及其應用于腫瘤細胞成像與治療研究，2015年-2018年；

2. 河北省自然科學基金(B2012201078)，滾環擴增RNA適配體無標記熒光成像原位檢測microRNA，2012年-2014年；

3. 國家自然科學基金(21075028)，恒溫擴增高通量高靈敏度熒光成像檢測microRNA 的研究，2011年-2013年；

4. 教育部高等學校博士學科點基金(20091301120003)，基于滾環擴增的microRNA 原位、高通量分析，2010年-2012年；

5. 河北省自然科學基金(B2009000170)，滾環擴增共軛聚合物熒光共振能量轉移高靈敏度檢測核酸的研究，2009年-2011年

四、代表性論文：

1. Yongqiang Cheng,* Lijuan Dong, Jiangyan Zhang, Yaqing Zhao, and Zhengping Li,* Recent advances in microRNA detection, Analyst, 2018, 143, 1758-1774.

2. Jingxiao Tian, Jiangyan Zhang, Jiangtao Yang, Lingyun Du, Hao Geng, and Yongqiang Cheng,* Conjugated Polymers Act Synergistically with Antibiotics to Combat Bacterial Drug Resistance, ACS Appl. Mater. Interfaces, 2017, 9, 18512-18520.

3. Yacui Liu, Jiangyan Zhang*, Jingxiao Tian, Xiaofei Fan, Hao Geng, Yongqiang Cheng*, Multiplex detection of microRNAs by combining molecular beacon probes with T7 exonuclease-assisted cyclic amplification reaction, Anal. Bioanal. Chem., 2017, 409, 107-114.

4. Likun Zhao, Jiangyan Zhang,* Huiming Xu, Hao Geng, and Yongqiang Cheng*, Conjugated Polymers/DNA Hybrid Materials for Protein Inactivation, ACS Appl. Mater. Interfaces, 2016, 8, 22923−22929.

5. Yuanyuan Zhou, Jiangyan Zhang, Likun Zhao, Yingcun Li, Hui Chen, Shengliang Li, and Yongqiang Cheng*, Visual Detection of Multiplex MicroRNAs Using Cationic Conjugated Polymer Materials, ACS Appl. Mater. Interfaces, 2016, 8, 1520-1526.

6. Yingcun Li, Jiangyan Zhang,* Jingjing Zhao, Likun Zhao, Yongqiang Cheng* and Zhengping Li, A simple molecular beacon with duplex-specific nuclease amplification for detection of microRNA, Analyst, 2016, 141, 1071-1076.

7. Zheng Yuan, Yuanyuan Zhou, Shuxin Gao, Yongqiang Cheng*, and Zhengping Li*, Homogeneous and Sensitive Detection of microRNA with Ligase Chain Reaction and Lambda Exonuclease-Assisted Cationic Conjugated Polymer Biosensing, ACS Appl. Mater. Interfaces, 2014, 6, 6181-6185.

8. Yongqiang Cheng*, Jingjing Zhao, Hailian Jia, Zheng Yuan and Zhengping Li*, Ligase chain reaction coupled with rolling circle amplification for high sensitivity detection of single nucleotide polymorphisms, Analyst, 2013, 138, 2958-2963.

9. Yongqiang Cheng*, Qing Du, Liyong Wang, Hailian Jia, and Zhengping Li*, Fluorescently Cationic Conjugated Polymer as an Indicator of Ligase Chain Reaction for Sensitive and Homogeneous Detection of Single Nucleotide Polymorphism, Analytical Chemistry, 2012, 84, 3739-3744.

10. Liyong Wang, Yongqiang Cheng,* Hui Wang, Zhengping Li*, A Homogeneous Fluorescence Sensing Platform with Water-soluble Carbon Nanoparticles for Detection of MicroRNA and Nuclease Activity, Analyst, 2012, 137, 3667-3672.

11. TANG ZhiYuan, CHENG YongQiang*, DU Qing, ZHANG HongXia & LI ZhengPing*, Integration of rolling circle amplification and cationic conjugated polymer for the homogeneous detection of single nucleotide polymorphisms, Chinese Science Bulletin, 2011, 56, 3247-3252.

12. Yongqiang Cheng, Xian Zhang, Zhengping Li, Xiaoxia Jiao, Yucong Wang, and Yali Zhang, Highly Sensitive Determination of microRNA Using Target-Primed and Branched Rolling-Circle Amplification, Angew. Chem. Int. Ed., 2009, 48, 3268-3272.

13. Yongqiang Cheng, Zhengping Li, Baoan Du, and Xian Zhang, Homogeneous and label-free bioluminescence detection of single nucleotide polymorphism with rolling circle amplification, Analyst, 2008, 133, 750-752.

14. Yongqiang Cheng, Zhengping Li, Xian Zhang, Baoan Du, Yongshan Fan, Homogeneous and label-free fluorescence detection of single-nucleotide polymorphism using target-primed branched rolling circle amplification, Anal. Biochem., 2008, 378，123-126.

15. Yongqiang Cheng, Zhengping Li, Yuqin Su, Yongshan Fan, Ferric nanoparticle-based resonance light scattering determination of DNA at nanogram levels, Talanta, 2007, 71, 1757-1761.