河北大學化學與環(huán)境科學學院研究生導師：張金超

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河北大學化學與環(huán)境科學學院研究生導師張金超介紹如下：

一、個人簡介

張金超, 浙江大學博士 (1998-2001)，北京大學博士后(2001-2003)，香港城市大學高級訪問學者(2003-2006)，現(xiàn)為教授，博士研究生導師，河北省自然科學基金杰出青年基金獲得者、河北省青年科技獎獲得者、河北省新世紀“三三三人才工程”第一層次人選、河北省高校百名優(yōu)秀創(chuàng)新人才、河北省政府特殊津

貼專家;現(xiàn)任河北大學科學技術處處長、藥物化學與分子診斷教育部重點實驗室常務副主任以及河北省化學生物學重點實驗室主任。迄今為止，發(fā)表SCI收錄論文150余篇;獲授權中國發(fā)明專利 20余項，先后主持了國家“重大新藥創(chuàng)制”科技重大專項、國家自然科學基金、教育部科學技術研究重點項目、河北省自

然科學基金杰出青年基金、河北省自然科學基金重點項目、河北省應用基礎研究計劃重點基礎研究項目等20余項課題。

聯(lián)系方式：E-mail: jczhang6970@163.com

二、主講課程及研究方向

1.主講課程：有機化學，生物無機化學，化學生物學

2.研究方向：納米醫(yī)學與分子診療。

三、代表性論文

1.Anil Kumar, Shuaidong Huo, Xu Zhang, Juan Liu, Aaron Tan, Shengliang Li, Shubin Jin, Xiangdong Xue, YuanYuan Zhao, Tianjiao Ji, Lu Han, Hong Liu, Xiaoning Zhang*, Jinchao Zhang*, Guozhang Zou, Tianyou Wang*, Suoqin Tang, and Xing-Jie Liang*. Neuropilin-1-targeted goldnanoparticles

enhance therapeutic efficacy of platinum(IV) drug for prostate cancer treatment. ACSNano, 2014, 8(5), 4205-4220.

2.Xiaohong Hao, Xixue Hu, Cuimiao Zhang, Shizhu Chen, Zhenhua Li, Xinjian Yang, Huifang Liu, Guang Jia,* Dandan Liu, Kun Ge, Xing-Jie Liang,* and Jinchao Zhang*. Hybrid mesoporous silica-based drug carrier nanostructures with improved degradability by hydroxyapatite. ACSNano, 2015, 9(10),

9614-9625.

3. Kun Ge, Cuimiao Zhang, Guang Jia,* Huihui Ren, Jianyuan Wang, Aaron Tan, Xing-Jie Liang,* Aimin Zang and Jinchao Zhang*. Defect-related luminescent mesoporous silica nanoparticles employed for novel detectable nanocarrier. ACS Appl. Mater Interfaces, 2015, 7, 10905-10914.

4.Yaqiong Dong, Jun Yang, Hongmei Liu, Tianyou Wang, Suoqin Tang, Jinchao Zhang* and Xin Zhang*. Site-specific drug-releasing polypeptide nanocarriers based on dual-pH response for enhanced therapeutic efficacy against drug-resistant tumors. Theranostics, 2015, 5(8), 890-904.

5.Ran Zhang, Yan Li, Bingbing Hu, Zhiguo Lu, Jinchao Zhang*, Xin Zhang*. Traceable nanoparticle delivery of small interfering RNA and retinoic acid with temporally release ability to control neural stem cell differentiation for Alzheimer’s disease therapy. Adv Mater, 2016, 28, 6345-6352.

6. Kun Ge, Cuimiao Zhang, Wentong Sun, Huifang Liu, Yi Jin, Zhenhua Li, Xing-Jie Liang, Guang Jia,* Jinchao Zhang*.Up-conversion Y2O3:Yb3+, Er3+ hollow spherical drug carrier with improved degradability for cancer treatment. ACS Appl Mater Interfaces, 2016, 8: 25078−25086.

7.Weipei Feng, Chunyue Gao, Wei Liu, Huihui Ren, Chao Wang, Kun Ge, Shenghui Li, Guoqiang Zhou, Hongyan Li, Shuxiang Wang,* Guang Jia, Zhenhua Li, Jinchao Zhang*. A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control. Chem Commun, 2016, 52, 9434-

9437.

8. Chao Wang, Dandan Liu, Cuimiao Zhang, Jiadong Sun, Weipei Feng, Xing-Jie Liang,Shuxiang Wang,* Jinchao Zhang*.Defect-related luminescent hydroxyapatite-enhanced osteogenic differentiation of bone mesenchymal stem cells via an ATP-induced cAMP/PKA pathway. ACS Appl Mater Interfaces,

2016, 8, 11262−11271.

9.Shizhu Chen, Keni Yang, Ruslan G. Tuguntaev, Anbu Mozhi, Jinchao Zhang*, Paul C. Wang, Xing-Jie Liang*. Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance. Nanomedicine: NBM, 2016, 12, 269–286.

10.Shizhu Chen, Xiaohong Hao, Xingjie Liang, Qun Zhang, Cuimiao Zhang, Guoqiang Zhou,Shigang Shen, Guang Jia, and Jinchao Zhang.Inorganic nanomaterials as carriers for drug delivery. J Biomed Nanotechnol, 2016, 12, 1-27.

11. Hongliang Li, Wen Peng, Weipei Feng, Yuechai Wang, G. Chen, Shuxiang Wang*, Shenghui Li, Hongyan Li, Kerang Wang, Jinchao Zhang*.A novel dual-emission fluorescent probe for the simultaneous detection of H2S and GSH. Chem. Commun., 2016, 52, 4628–4631.

12. Fei Duan, Xiaochen Feng, Xinjian Yang, Wentong Sun, Yi Jin, Huifang Liu, Kun Ge, Zhenhua Li*, Jinchao Zhang*. A simple and powerful co-delivery system based on pH-responsive metal-organic frameworks for enhanced cancer immunotherapy. Biomaterials, 2017, 122, 23-33.

13. Huifang Liu, Yi Jin, Kun Ge, Guang Jia, Zhenhua Li, Xinjian Yang, Shizhu Chen, Min Ge, Wentong Sun, Dandan Liu*, and Jinchao Zhang*. Europium-doped Gd2O3 nanotubes increase bone mineral density in vivo and promote mineralization in vitro. ACS Appl. Mater. Interfaces, 2017, 9, 5784-5792.

14. Yi Jin, Zhenhua Li, Huifang Liu, Shizhu Chen, Feng Wang, Ling Wang, Nan Li, Kun Ge, Xinjian Yang*, Xing-Jie Liang*, Jinchao Zhang*. Biodegradable, multifunctional DNAzyme nanoflowers for enhanced cancer therapy. NPG Asia Materials, 2017, 9, e365.

15.Fei Duan, Xiaochen Feng, Yan Jin, Dawei Liu, Xinjian Yang, Guoqiang Zhou, Dandan Liu, Zhenhua Li*, Xing-Jie Liang*, Jinchao Zhang*.Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of MRSA. Biomaterials, 2017, 144, 155-165.

16.Shutao Gao, Pengli Zheng, Zhenhua Li*, Xiaochen Feng, Weixiao Yan, Shizhu Chen, Weisheng Guo, Dandan Liu, Xinjian Yang, Shuxiang Wang, Xing-Jie Liang*, Jinchao Zhang*. Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic

tumor. Biomaterials, 2018, 178, 83-94.

17. Hongliang Li, Weiyan Lei, Jianong Wu, Shenghui Li, Guoqiang Zhou,* Dandan Liu, Xinjian Yang, Shuxiang Wang,* Zhenhua Li and Jinchao Zhang*. An upconverting nanotheranostic agent activated by hypoxia combined with NIR irradiation for selective hypoxia imaging and tumour therapy.J. Mater.

Chem. B, 2018, 6, 2747-2757.

四、科研項目

1.人工稀土納米材料對骨髓基質細胞成骨分化和成脂分化的調控及分子機制(項目批準號：21271059), 國家自然科學基金項目( 2013-2016年, 主持人)

2.基于PH響應、可將接介孔二氧化硅/磷灰石復合納米顆粒的制備及其在抗腫瘤方面的應用(項目批準號：31470961), 國家自然科學基金項目(2014-2017年, 主持人)

3. 靶向腫瘤干細胞的多功能磁性二氧化硅納米載藥體系的構建及其抗腫瘤作用研究(項目批準號：B2017201226)，河北省自然科學基金重點項目(2017-2019年， 主持人)

五、獲獎

1.異常骨吸收防治的基礎和應用研究，2009年河北省科技進步三等獎(第二名)

2.骨質疏松癥防治的基礎與應用研究，2017年河北省科技進步三等獎(第一名)