河北大學化學與環境科學學院研究生導師：王書香

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河北大學化學與環境科學學院研究生導師王書香介紹如下：

一、個人簡介

王書香, 男, 生于1965年11月，河北省廊坊大城縣人。博士，教授，碩士研究生導師。迄今為止，發表SCI收錄論文40余篇;獲中國發明專利授權2項，曽主持和參與科研課題多項。2007年度獲河北省科技進步三等獎。2014年獲河北省自然科學二等獎。

聯系方式：E-mail: wsx@hbu.edu.cn

二、主講課程及研究方向

1.主講課程：有機化學

2.研究方向：有機合成、藥物化學、小分子探針

三、代表性論文

1. Shuxiang Wang*, Wenqing Shao, Hongdong Li, Cui Liu, Ke Wang, Jinchao Zhang*. Synthesis, characterization and cytotoxicity of the gold(III) complexes of 4,5-dihydropyrazole-1-carbothioamide derivatives. Eur J Med Chem., 2011, 46, 1914-1918.

2. Shuxiang Wang, Hongdong Li, Chao Chen, Jinchao Zhang*, Shenghui Li, Xinying Qin, Xiaoliu Li*, Kerang Wang. Cytotoxicity and DNA binding property of phenanthrene imidazole with polyglycol side chains. Bioorg Med Chem Lett., 2012, 22: 6347–6351.

3. Shuxiang Wang*, Yanan Shi, Wenqing Shao, Jianlong Du, Haiying Wei, Jinchao Zhang*, Ke Wang, Shigang Shen, Shenghui Li, Jitai Li and Yangyang Zhao.Synthesis, characterization and cytotoxicity of gold(III) complexes with deprotonated pyridyl carboxamide. Appl. Organometal. Chem. (2012)

4. Yanan Shi, Wenhao Chu, Yuechai Wang, Shuxiang Wang*, Jianlong Du, Jinchao Zhang*, Shenghui Li, Guoqiang Zhou, Xinying Qin, Chenliang Zhang. Synthesis, characterization and cytotoxicity of the Au(III) complexes with cyclic amine-based dithiocarbamate ligands. Inorganic Chemistry

Communications, 2013, 30: 178–181.

5. Shizhu Chen, Yingjian Hou, Gong Cheng, Cuimiao Zhang, Shuxiang Wang*, Jinchao Zhang*. Cerium Oxide Nanoparticles Protect Endothelial Cells from Apoptosis Induced by Oxidative Stress. Biol Trace Elem Res, 2013, 154, 156–166.

6. Shuxiang Wang*, Wenhao Chu, Yuechai Wang, Siyuan Liu, Jinchao Zhang, Shenghui Li, Haiying Wei, Guoqiang Zhou, Xinying Qin. Synthesis, characterization and cytotoxicity of Pt(II), Pd(II), Cu(II) and Zn(II) complexes with 4’-substituted terpyridine. Appl Organometal Chem, 2013, 27, 373–379.

7. Wenhao Chu, Yuechai Wang, Siyuan Liu, Xueyun Yang, Shuxiang Wang*, Shenghui Li, Guoqiang Zhou, Xinying Qin, Chuanqi Zhou, Jinchao Zhang*. Synthesis, cytotoxicity and DNA-binding properties of Pd(II), Cu(II) and Zn(II) complexes with 4¢-(4-(2-(piperidin-1-yl)ethoxy)phenyl)- 2,2’:6’,2’’-terpyridine.

Bioorg Med Chem Lett., 2013, 23: 5187–5191.

8. Cui Liu, Siyuan Liu, Yuechai Wang, Shuxiang Wang*, Jinchao Zhang*, Shenghui Li, Xinying Qin,Xiaoliu Li, Kerang Wang,Quoqiang Zhou. Synthesis, cytotoxicity, and DNA-binding property of berberine derivatives. Med Chem Res, 2014, 23:1899–1907.

9. Shizhu Chen, Cuimiao Zhang, Guang Jia, Jianlei Duan, ShuxiangWang*, Jinchao Zhang*. Size-dependent cytotoxicity of europium doped NaYF4nanoparticles in endothelial cells. Materials Science and Engineering C, 2014, 43: 330–342.

四、科研項目

1.2011.01-2013.12: 主持河北省自然科學基金：二茂鐵基環Au(III)化合物的設計、合成與抗腫瘤活性研究

2. 2012.01-2014.12: 主持河北省教育廳重點項目：新型Co(III)配合物類乏氧激活性抗腫瘤前藥的設計、合成與篩選

3. 2015-2017主持河北省應用基礎研究計劃重點基礎研究項目：茚(1,2-b)喹喔啉-5,10-二氧-11-酮肟醚類乏氧激活性抗腫瘤前藥的設計、合成與抗腫瘤機制研究

五、授權專利

1. 發明人：王書香，張金超, 李勝輝，秦新英，宋長英，邵文慶. 具有抗腫瘤活性酰胺類Au(III)配合物、制備方法及應用. 專利號：ZL 201110157868.9