河北大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院研究生導(dǎo)師：李勝輝

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河北大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院研究生導(dǎo)師李勝輝介紹如下：

一、個(gè)人簡介

李勝輝：男，理學(xué)博士，教授，碩士研究生導(dǎo)師。2005年畢業(yè)于中國科學(xué)院化學(xué)研究所，高分子化學(xué)與物理專業(yè)。1995年工作以來，參加多項(xiàng)國家自然科學(xué)基金、科技部973計(jì)劃前期研究專項(xiàng)及中國科學(xué)院“引進(jìn)國外杰出人才、百人計(jì)劃”等課題的研究，主持河北省自然科學(xué)基金2項(xiàng)。目前主要從事基于生物活

性配體的配位誘導(dǎo)金屬有機(jī)超分子及具有抗腫瘤活性天然有機(jī)小分子類似物的設(shè)計(jì)、合成及作用機(jī)制研究。先后在Organ. Lett., Bioorg. Med. Chem. Lett.，Curr. Organ. Chem.,Dalton Trans., Inorg. Chem., Inorg. Chem. Commun.,等雜志上發(fā)表學(xué)術(shù)論文30余篇。

email：lish@hbu.edu.cn

二、主講課程及研究方向

1.主講課程：有機(jī)化學(xué)，物理有機(jī)化學(xué)

2.研究方向：化學(xué)生物學(xué)、超分子化學(xué)

三、科研項(xiàng)目

1. 河北省自然科學(xué)基金：靶向G-四鏈體的11-N-甲基吲哚[2,3-b]喹喔啉衍生物的設(shè)計(jì)、合成及抗腫瘤活性研究(項(xiàng)目編號：B2015201213， 2015-2017，主持人)

2. 河北省自然科學(xué)基金-石藥集團(tuán)醫(yī)藥聯(lián)合研究基金：多金屬中心G-四鏈體結(jié)合劑的設(shè)計(jì)、合成及抗腫瘤活性研究(項(xiàng)目編號：B2011201174， 2011-2013，主持人)

3. 科技部973計(jì)劃前期研究專項(xiàng)：基于DNA靶標(biāo)的多效價(jià)抗腫瘤藥物的研究(項(xiàng)目編號：2010CB534913，2010-2012，第六參加人)

4. 河北省自然科學(xué)基金：功能化多孔性配位聚合物的制備(項(xiàng)目編號：B2007000152，2007-2009，第二完成人)

5. 橫向課題-“新型染料中間體開發(fā)” (項(xiàng)目編號：2008-15，主持人)

四、代表性論文

1. Shenghui Li*, Shengjie Xu, Yonghe Tang, Shan Ding, Jinchao Zhang, Shuxiang Wang, Guoqiang Zhou, Chuanqi Zhou, Xiaoliu Li, Synthesis, anticancer activity and DNA-binding properties of novel 4-pyrazolyl-1,8-naphthalimide derivatives, Bioorg. Med. Chem. Lett., 2014, 24(2), 586-590.

2. Shenghui Li ，Shengjie Xu， Shan Ding， Jinchao Zhang，Shuxiang Wang， Xiaoliu Li，Synthesis and biological evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents，Res Chem Intermed, 2014, 40(4), 1459-1468.

3. Shenghui Li, Shan Ding, Shengjie Xu, Jinchao Zhang, Shuxiang Wang, Chuanqi Zhou, Xiaoliu Li, Iodine-catalyzed three-component one-pot synthesis of novel 1,8-dioxo-decahydroacridines derivatives bearing benzene sulfonamide moiety, Res Chem Intermed, 2014, 40(5), 2091-2102.

4. Shengjie Xu, Shenghui Li*, Yonghe Tang, Jinchao Zhang, Shuxiang Wang, Chuanqi Zhou, Xiaoliu Li, Design, synthesis, and biologic evaluation of some novel N-arylpyrazole derivatives as cytotoxic agents, Med Chem Res, 2013, 22, 5610-5616.

5. Shu-Yan Yu; Qing Jiao; Sheng-Hui Li; Hai-Ping Huang; Yi-Zhi Li; Yuan-Jiang Pan; Yoshihisa Sei; and Kentaro Yamaguchi; Self-Assembly of Tripyrazolate-Linked Macrotricyclic M12L4 Cages with Dimetallic Clips, Organic Letters, 2007, 9(7): 1379-1382

6. LI Sheng-Hui; HUANG Hai-Ping; YU Shu-Yan; LI Xian-Ping, Design and Synthesis of Polypyrazolyl Compounds as a New Type of Versatile Building Blocks, Chinese Journal of Chemistry, 2006, 24, 1225-1229

7. Sheng-Hui Li; Hai-Ping Huang; Shu-Yan Yu*; Yi-Zhi Li*; Yoshihisa Sei, Kentaro Yamaguchi, Self-assembly of coordination molecular baskets as inorganic analogues of cyclotriveratrylenes (CTV), Dalton Transactions, 2005, 2346-2348.

8. Shu-Yan Yu*; Sheng-Hui Li; Hai-Ping Huang; Zhong-Xing Zhang; Qing Jiao; Hong Shen; Xi-Xue Hu; Hui Huang; Molecular Self-Assembly with Modularization and Directionality: Vector-Manipulation at Metal Centers, Current Organic Chemistry, 2005, 9, 555-563

9 Shu-Yan Yu, Hai-Ping Huang, Sheng-Hui Li, Qing Jiao, Yi–Zhi Li, Biao Wu, Yoshihisa Sei, Kentaro Yamaguchi, Yuan-Jiang Pan and Hong-Wei Ma, Solution Self-Assembly, Spontaneous Deprotonation, and Crystal Structures of Bipyrazolate-Bridged Metallomacrocycles with Dimetal Centers, Inorgic

Chemistry, 2005, 44，9471-9488.

10. Hai-Ping Huang; Sheng-Hui Li; Shu-Yan Yu*; Yi-Zhi Li*; Qing Jiao; Yuan-Jiang Pan, Novel pyrazolate-bridged dinuclear Pd(II) diimine complexes that bind inorganic anions, Inorganic Chemistry Communications, 2005, 8, 656-660.

五、獲獎(jiǎng)情況

1. 一類新的生物標(biāo)志化合物：甲基三環(huán)萜烷的合成研究(河北省科學(xué)技術(shù)獎(jiǎng)：三等獎(jiǎng)，2002年4月，第五參加人)

2. 穩(wěn)定臭氧化物的合成及性質(zhì)研究(河北省科學(xué)技術(shù)獎(jiǎng)：三等獎(jiǎng)，2003年5月，第三參加人)