第四軍醫(yī)大學(xué)藥學(xué)系碩導(dǎo)介紹：李小強(qiáng)

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姓名：李小強(qiáng)

性別：男　

職稱：副教授

學(xué)院：藥學(xué)系

李小強(qiáng)，第四軍醫(yī)大學(xué)藥理學(xué)教研室副教授、副主任，碩士研究生導(dǎo)師，陜西省藥品保健食品審評(píng)專家。中國(guó)藥理學(xué)會(huì)、中國(guó)生物物理學(xué)會(huì)和美國(guó)生物物理學(xué)會(huì)會(huì)員。1999年畢業(yè)于西安交通大學(xué)藥學(xué)院，獲學(xué)士學(xué)位，畢業(yè)后參軍入伍至第四軍醫(yī)大學(xué)藥理學(xué)教研室工作。2007年6月獲第四軍醫(yī)大學(xué)醫(yī)學(xué)博士學(xué)位（學(xué)校首批碩-博連讀生）。2006年4月至2008年6月，赴美國(guó)Albany醫(yī)學(xué)院心血管科學(xué)研究中心進(jìn)行博士研究生聯(lián)合培養(yǎng)和博士后研究工作。

目前負(fù)責(zé)國(guó)家自然科學(xué)基金課題2項(xiàng)、陜西省科技計(jì)劃項(xiàng)目1項(xiàng)、分題負(fù)責(zé)十一五國(guó)家“重大新藥創(chuàng)制”課題1項(xiàng)，2009年獲第四軍醫(yī)大學(xué)“青年英才支持計(jì)劃（第二層次）”研究基金資助；以主要完成人參與其他國(guó)家、軍隊(duì)、省部級(jí)課題10余項(xiàng)。

發(fā)表研究論文43篇，其中SCI收錄期刊20余篇；擔(dān)任Journal of Pharmacy and Pharmacology，International Immunopharmacology，《心臟雜志》和《細(xì)胞與分子免疫學(xué)雜志》等國(guó)內(nèi)外期刊審稿人；申請(qǐng)國(guó)家發(fā)明專利2項(xiàng)。

任教以來(lái)，主講藥理學(xué)、臨床藥理學(xué)、臨床藥物治療學(xué)等課程，發(fā)表教學(xué)論文3篇，主編校內(nèi)教材1部，參編專著4部，2011年獲第四軍醫(yī)大學(xué)“精品教員”稱號(hào)；曾多次獲嘉獎(jiǎng)，榮立個(gè)人“三等功”1次。

研究方向：（1）離子通道在相關(guān)疾病中調(diào)控機(jī)制的基礎(chǔ)及應(yīng)用研究；（2）活性天然產(chǎn)物的藥理作用及新藥研究。
 
發(fā)表的主要文章（*為通訊作者）：

1. Li XQ, Cao W, Zeng AG, Yang ZF, Xing B, Dong L, Zhang HF, Mei QB*. Different pharmacological properties of the optical isomers of MN9202, a novel 1,4-dihydropyridine Ca2+ channel modulator in rat ventricular myocytes. Clin Exp Pharmacol Physiol. 2010;37(8):817-825.

2. Li XQ, Zheng YM, Rathore R, Ma J, Takeshima H, Wang YX*. Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells. Pflugers Arch. 2009;457(4): 771-783.

3. Li XQ*, Cao W, Li T, Zeng AG, Hao LL, Zhang XN, Mei QB. Amlodipine inhibits TNF-alpha production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway. Int Immunopharmacol. 2009;9(9):1032-1041.

4. Li XQ, Zhao MG, Mei QB*, Zhang YF, Guo W, Wang HF, Chen D, Cui Y. Effects of tumor necrosis factor-alpha on calcium movement in rat ventricular myocytes. Acta Pharmacol Sin. 2003; 24(12): 1224-1230.

5. Li XQ, Zheng YM, Wang YX*. Functional importance of type-1 ryanodine receptor in smooth muscle cells. Biophysical Journal. 2008, 94(2) : 877-880.

6. Cao W, Li XQ*, Zhang XN, Hou Y, Zeng AG, Xie YH, Wang SW*. Madecassoside suppresses LPS- induced TNF-alpha production in cardiomyocytes through inhibition of ERK, p38, and NF-kappaB activity. Int Immunopharmacol. 2010;10(7):723-729.

7. Cao W, Xie YH, Li XQ*, Zhang XK, Chen YT, Kang R, Chen X, Miao S, Wang SW*. Burn-induced apoptosis of cardiomyocytes is survivin dependent and regulated by PI3K/Akt, p38 MAPK and ERK pathways. Basic Res Cardiol. 2011 Jun 26.

8. Cao W, Li XQ(co-first), Wang X, Li T, Chen X, Liu SB, Mei QB*. Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels. Int J Biol Macromol. 2010;46(1):115-122.

9. Cao W, Li XQ(co-first), Wang X, Fan HT, Zhang XN, Hou Y, Liu SB, Mei QB*. A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway. Phytomedicine. 2010;17(8-9):598-605.

10. Cao W, Li XQ, Liu L, Yang TH, Li C, Fan HT, Jia M, Lv ZG, Mei QB*. Structure of an anti-tumor polysaccharide from Angelica sinensis (Oliv.) Diels. Carbohydr Polymers. 2006;66(2):149-159.

11. Cao W, Li XQ, Liu L, Wang M, Fan HT, Li C, Lv Z, Wang X, Mei Q*. Structural analysis of water-soluble glucans from the root of Angelica sinensis (Oliv.) Diels. Carbohydr Res. 2006; 341 (11):1870-1877.

12. Rathore R, Zheng YM, Li XQ, Wang QS, Liu QH, Ginnan R, Singer HA, Ho YS, Wang YX*. Mitochondrial ROS-PKCepsilon signaling axis is uniquely involved in hypoxic increase in[Ca2+]i in pulmonary artery smooth muscle cells. Biochem Biophys Res Commun. 2006;351(3):784-790.

13. Liu QH, Zheng YM, Li XQ, Ma JJ, Takeshima H, Wang YX*. PKC epsilon Regulates Calcium Sparks By Selectively Interacting With Type-1 Ryanodine Receptors In Smooth Muscle Cells. Biophysical Journal. 2008, 94(2) : 150-157.

14. Liu QH, Zheng YM, Korde AS, Li XQ, Ma J, Takeshima H, Wang YX*. Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells. Am J Respir Cell Mol Biol. 2009; 40(6):663-671.

15. Zhao MG, Mei QB, Zhang YF, Xing B, Li XQ, Cui Y. Inhibitory effects of serotonin on transient outward potassium current in rat ventricular myocytes. Acta Pharmacol Sin. 2002;23(7):617-622.