蘭州大學生命科學學院導師介紹：劉恒

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學習經歷

1988年至1993年在蘭州醫學院（現蘭州大學公共衛生學院）預防醫學系讀本科，獲學士學位。

1995年至1998年在蘭州醫學院（現蘭州大學基礎醫學院）生理學研究室師從瞿頌義教授獲碩士學位。

1998年至2002年在蘭州大學生命科學學院細胞生物學研究所師從鄭國锠院士獲博士學位。

09/1998-12/2002Ph.D.LanZhou UniversityMajor in Cell Biology

09/1995-09/1998M.D. LanZhou Medical College Major in Physiology

09/1988-06/1993B.M. LanZhou Medical College Major in Preventive Medicine

工作經歷

1993年至1995年在甘肅省勞動衛生與職業病防治研究所監督科（現甘肅省衛生廳衛生監督所）工作。

1999年5月至1999年12月在中科院上海植生所植物分子遺傳國家重點實驗室黃海課題組客座研究。

2001年9月至2002年11月在中科院上海植生所植物分子遺傳國家重點實驗室何玉科課題組客座研究。

2003年7月至2004年8月在美國Case Western Reserve University生化系Dr.HungYing Kao實驗室從事博士后研究。

2004至2014在蘭州大學生命科學學院細胞生物學研究所副教授。

2012年9月至2013年9月在美國Cornell University, Plant Biology Department, Jian Hua實驗室訪問學者。

2014年月至今在蘭州大學生命科學學院教授

05/2014-now profesor in Life science school,Lanzhou Univesity

09/2012-09/2013Visiting Scholar in Plant Biology Department Cornell University in USA

08/2004-05/2014associate professor in Institute of Cell Biology,Life science School,Lanzhou University

07/2003-08/2004postdoc/research associate in Hungying Kao’s lab in Biochemistry Department in CWRU(CASE) in USA

01/2003-07/2003research assistant and teacher in Institute of Cell Biology in Lanzhou University

09/2001-11/2002 cooperative laboratory assistant(Yuke He’s lab) in Shanghai Institute of Plant Physiology & Ecology of China Academy of Science (CAS)

05/1999-12/1999 cooperative laboratory assistant(Hai Huang’s lab) in Shanghai Institute of Plant Physiology & Ecology of China Academy of Science (CAS)

06/1993-09/1995 occupational disease doctor and sanitary supervisor of occupational health of China in Institute of Occupational Health and Disease of GanSu Province

教學及指導研究生情況

承擔本科生《細胞生物學》（省級精品課程）《生物信息學》的教學。
指導碩士研究生（畢業30人，在讀9人）；協助鄭國锠院士指導博士研究生（已畢業10名，在讀3名）。
 
發表論文及專著

代表性論文，下劃線為通訊作者（ correspondance）

2013

Overexpression of Small Heat Shock Protein LimHSP16.45 in Arabidopsis Enhances Tolerance to Abiotic Stresses. Mu C, Zhang S, Yu G, Chen N, Li X, Liu H. PLoS ONE 2013,8(12): e82264. doi:10.1371/journal.pone.0082264
 
MAIGO2 is involved in abscisic acid-mediated response to abiotic stresses and Golgi-to-ER retrograde transport. Zhao P, Liu F, Zhang B, Liu X, Wang B, Gong J, Yu G, Ma M, Lu Y, Sun J, Wang Z, Jia P, Heng Liu. Physiol Plant. 2013 Jun;148(2):246-60. doi: 10.1111/j.1399-3054.2012.01704.x.
 
Yue Niu, Yuping Wang,, Ping Li, Feng Zhang, Heng Liu, Guochang Zheng. Drought stress induces oxidative stress and the antioxidant defense system in ascorbate-deficient vtc1 mutants of Arabidopsis thaliana. Acta Physiol Plant (2013) 35:1189–1200.
 
AtSec20 is involved in osmotic stress tolerance and AtSec20 mutation unaffects the integrity of intracellular organelles and the anterograde biosynthetic trafficking. Pengshan Zhao, Fei Liu, Bing Wang, Guanzhong Yu, Pengfei Jia and Heng Liu. Acta Physiol Plant (2013) 35:1625–1632. DOI: 10.1007/s11738-012-1205-6.
 
2012

Hao Yin, Bo Yan, Jing Sun, Pengfei Jia, Zijuan Zhang, Xiaosa Yan, Juan Chai, Zhizhong Ren, Guochang Zheng, Heng Liu. Graft-union development: a delicate process that involves cell–cell communication between scion and stock for local auxin accumulation. J Exp Bot. 2012,Jun;63(11):4219-32.(IF2012: 5.364)

生長素類化合物及6-苯甲基腺嘌呤對擬南芥主根生長的抑制效應比較. 李曉峰,孟廣目,梁城磊,李丹,張瑞婷,牟長軍,陳倪,劉恒. 植物生理學報,2012, 48 (4): 403-407.

Analysis of Highly Expressed Genes in the Late Zygotene to Pachytene Stages of Meiotic Prophase I in David Lily. Changjun Mu, Shaobo Wang, Jiajia Pan,Shijia Zhang, Guanzhong Yu,Ni Chen, Zhaoyan Wang , Heng Liu. Russ J Plant Physiol. 2012, 59, 3, 389–397.

2011

Changjun Mu, Shaobo Wang, Shijia Zhang, Jiajia Pan, Ni Chen, Xiaofeng Li, Zhaoyan Wang ，Heng Liu. Small heat shock protein LimHSP16.45 protects pollen mother cells and tapetal cells against extreme temperatures during late zygotene to pachytene stages of meiotic prophase I in David Lily. Plant Cell Rep,2011,30:1981–1989.
 
PengShan Zhao, Fei Liu,GuoChang Zheng,Heng Liu. Group 3. late embryogenesis abundant protein in Arabidopsis:structure, regulation, and function. Acta Physiol Plant,2011,33:1063–1073.
 
Pengshan Zhao,Fei Liu,Miao Ma,Jiao Gong,Qiujun Wang,Pengfei Jia,Guochang Zheng,Heng Liu. Overexpression of AtLEA3-3 Confers Resistance to Cold Stress in Escherichia coli and Provides Enhanced Osmotic Stress Tolerance and ABA Sensitivity in Arabidopsis thaliana. Molecular Biology, 2011, 45, 5, 785–796.
 
Ping Cao, Jing Sun, Peng Zhao, Heng Liu* and Guochang Zheng. A new putative plasmodesmata-associated protein, At1g19190, in Arabidopsis. Afr. J. Biotechnol. 2011,10(76), 17409-17423.

2010：

Yuanhong Zhang, Junjie Wang, Pengfei Jia, XiaoqiangYu, Heng Liu, Xin Liu, Ning Zhao,Baibiao Huang. Two-photon fluorescence imaging of DNA in living plant turbid tissue with carbazole dicationic salt. Org Biomol Chem. 2010 Oct 21;8(20):4582-8. 
 

Zhiqiang Yan, Dawei Liang, Heng Liu, Guochang Zheng. FLC: A Key Regulator of Flowering Time in Arabidopsis. Russ J Plant Physiol2010, vol 57.2.166-174.

Xiaofeng Li, Guangmu Meng, Fei Ha, Lu Huo, Jian Wang, Shaobo Wang, Guochang Zheng, Heng Liu. Interactions of Auxin and Gibberellin in the Control of Basal Growth of Arabidopsis Rosette Leaves. Russ J Plant Physiol2010, vol 57.6.815-825.
 
Changjun Mu, Ni Chen, Xiaofeng Li, Pengfei Jia, Zhaoyan Wang, Heng Liu. F-box Protein Arabidillo-1 Promotes Lateral Root Development by Depressing the Functioning of GA3 in Arabidopsis. J.Plant Biol.(2010)53:374-380.

賈鵬飛, 劉恒, 張元紅,劉鑫, 趙寧,于曉強，用于細胞核成像的2,7-BHVC雙光子熒光探針 高等學校化學學報，2010， 31（6），1075-1077.
 
2009:

Ni Chen, Yan Liu, Xin Liu, Juan Chai , Zhong Hu, Heng Liu. Enhanced Tolerance to Water Deficit and Salinity Stress in Transgenic Lycium barbarum L. Plants Ectopically Expressing ATHK1, an Arabidopsis thaliana HistidineKinase Gene. Plant Mol Biol Rep.2009,27,321-333. 
 

劉鑫，劉恒，賈鵬飛，張波，王軍杰，趙寧，張元紅，于曉強. 一種用于細胞核成像的新型雙光子熒光探針,高等學校化學學報. 2009，30，465-467.

Qiong Wu, Tao Liu, Heng Liu, Guochang Zheng. Unsaturated fatty acid: Metabolism, synthesis and gene regulation.Afr. J. Biotechnol. 2009Vol. 8 (9)1782-1785.
 
Pinxian Xi, Liang Huang, Heng Liu, Pengfei Jia, Fengjuan Chen, Min Xu, Zhengzhi Zeng. Dual-rhodamine urea derivative, a novel chemidosimeterfor Hg(II )and its application in imaging Hg(II) in living cells. J Biol Inorg Chem.2009, 14:815-819.
 
2008:

Yujian Lu, Nan Yao, Xin Liu, Ni Chen, Heng Liu. Progress in studies of Zw10, a proper chromosome segregation protein. Biol Membrany. 2008,25,2, 97-110.

2007:

Heng Liu, Guangqin Guo, Yuke He, Yuping lu, Guo-Chang Zheng. Visualization on Intercellular movement of chromatin in intact living anthers of transgenic tobacco expressing histone 2B-CFP Fusion Protein. Caryologia. 2007,60(1):1-20.
 
Changjun Mu, Heng Liu, Guo-Chang Zheng. The modification and variants of histone. Molecular Biology. 2007, 41(3):349-360.

Changjun Mu, Pengfei Jia, Zhiqiang Yan, Xin Liu, Xiaofeng Li, Heng Liu. Quercetin induces cell-cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in HepG2. Methods Find Exp Clin Pharmacol. 2007, 29(3):179-183.
 
Erin L. Reineke，Heng Liu, Minh Lam, Yu Liu and Hung-Ying Kao. Aberrant association of PML-RARalpha with co-activators contributes to its ability to regulate gene expression. J Biol Chem. 2007 , 282(25):18584-96.
 
樊玉芳,姚南,陸玉建,劉恒. EB1蛋白在調節微管動態、紡錘絲定位和染色體穩定性中的作用. 陜西師范大學學報（自然科學版）.2007,35,95-98.
 
2004:

Heng Liu, Chong-Kuang Shaw, Erin L. Reineke, Yu Liu, and Hung-Ying Kao. Retinoid X Receptorα(RXRα) Helix 12 Plays an Inhibitory Role in the Recruitment of the p160 Co-activators by Unliganded RXRα/Retinoic Acid Receptor α Heterodimers. J Biol Chem. 2004 ;279(43):45208-18.
 
研究方向

本課題組的研究方向是：植物細胞信號轉導、植物功能基因組學。

.Warm-blooded animals use the thermoregulation to keep its body temperature and response to environment. Plant still has a temperature regulation system to survive in external environment. My research interesting is to understand the molecular mechnisms of the temperature regulating plant development,especially some of important cell activities,for examply,the cell cell communication between two or more plant cells,nucleo-cytoplasmic shuttling and so on.

梭梭引種肉蓯蓉荒漠化防治的示范基地建設及推廣：長期以來，荒漠化防治是事關我國西北，特別是甘肅省生存問題的大事。目前我們已經在甘肅民勤等地建成示范基地400畝。沿巴丹吉林沙漠從東到西，選取不同含水量的沙漠成功實施了梭梭引種肉蓯蓉荒漠化防治的示范基地建設。這一應用研究的推廣在荒漠化防治中具有深遠而重要的意義。

歡迎有志于植物分子細胞生物學研究的青年學子報考研究生。

項目成果

目前主持國家自然科學基金面上項目一項。

已經結題的作為主持人的科研項目：

教育部科學研究重大項目一項。
國家自然科學基金面上項目一項。
教育部春暉計劃一項。
甘肅省農業科技專項一項。
甘肅省農業生物技術研究與應用開發項目一項。
甘肅省科技廳成果鑒定：一種提高管花肉蓯蓉愈傷組織主要藥用成分的細胞工程技術。成果鑒定號：甘科鑒字2006第284號。

參與編寫“細胞生物學實驗（第三版）”

榮譽、獲獎

教育部新世紀優秀人才支持計劃（2011年）

社會工作

其它信息

2007年9月在德國zeiss公司接受激光共聚焦和雙光子技術培訓。

01/sept/2007-15/sept/2007 cofocal and two photon mocroscopy training in Jena,Germany