蘭州大學(xué)生命科學(xué)學(xué)院導(dǎo)師介紹：郭光沁

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學(xué)習(xí)經(jīng)歷

2000：蘭州大學(xué)，博士；
1995-1996：德國馬普研究所（科隆），歐盟瑪麗.居里獎學(xué)金；
1987：蘭州大學(xué)細胞生物學(xué)專業(yè)，碩士；
1984：蘭州大學(xué)生物系，學(xué)士。

Ph.D. Lanzhou University, 2000.
Marie Curie scholarship, Max-Planck institute, Germany, 1995-1996.
M.S. Lanzhou University, 1987.
B.S. Lanzhou University, 1984.

工作經(jīng)歷

2003- ：蘭州大學(xué)，教授，博士生導(dǎo)師；
1996-2003：蘭州大學(xué)，副教授；
1990-1992：植物分子遺傳國家重點實驗室，客座；
1987-1996：山東大學(xué)，助教、講師。

Professor, Lanzhou University, 2003-.
Associated Professor, Lanzhou University, 1996-2003.
Assistant Professor, Lecturer, Shandong University, 1987-1996.
Visiting scholar, State Key Laboratory of Plant Molecular Genetics, 1990-1992.

教學(xué)及指導(dǎo)研究生情況

發(fā)表論文及專著

Di DW, Zhang C, Luo P, An CW, Guo GQ. 2015. The biosynthesis of auxin: How many paths truly lead to IAA? Plant Growth Regulation doi: 10.1007/s10725-015-0103-5.

Wu L, Pan L, Di DW, Wang L, Wang M, Lu CK, Wei SD, Zhang L, Zhang TZ, Amakorová P, Mrvková M, Novák O, Guo GQ*. 2015. Forward genetic screen for auxin-deficient mutants by cytokinin. Sci Rep 5, 11923; doi: 10.1038/srep11923.

Wu L, Zhou ZY, Zhang CG, Chai J, Zhou Q, Wang L, Hirnerová E, Mrvková M, Novák O, Guo GQ*. 2015. Functional roles of three cutin biosynthetic acyltransferases in cytokinin responses and skotomorphogenesis. PLoS One 10(3): e0121943; doi: 10.1371/journal.pone.0121943.

Di DW, Zhang C, Guo GQ. 2015. Involvement of secondary messengers and small organic molecules in auxin perception and signaling. Plant Cell Rep 34(6):895-904.

Wu L, Di D-W, Zhang D, Song B, Luo P, Guo GQ. 2015. Frequent problems and their resolutions by using thermal asymmetric interlaced PCR (TAIL-PCR) to clone genes in Arabidopsis T-DNA tagged mutants. Biotechnol & Biotechnol Equipment 29(2): 260-267.

Zhao L, Liu P, Guo G*, Wang L*. 2015. Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells. Mol Med Rep 12: 719-727.
Zhou ZY, Zhang CG, Wu L, Zhang CG, Chai J, Wang M, Jha A, Jia PF, Cui SJ, Yang M, Chen R, Guo GQ*. 2011. Functional characterization of the CKRC1/TAA1 gene and dissection of hormonal actions in the Arabidopsis root. Plant J 66: 516–527.
Zhou Y, Zhang J, Lin H, Guo GQ, Guo Y. 2010. MORPHEUS’ MOLECULE1 is required to prevent aberrant RNA transcriptional read-through in Arabidopsis. Plant Physiol 154: 1272–1280.
Zhang CG, Guo HH, Zhang J, Guo GQ, Schumaker K, Guo Y. 2010. Arabidopsis CSAat1A and CSAat1B proteins form a complex with CULLIN4 and DDB1A and regulate the response to UV irradiation. Plant Cell 22: 2353-2369.
Liu Y, Yan Z, Chen N, Di X, Huang J, Guo G*. 2010. Development and function of central cell in angiosperm female gametophyte. Genesis (Dev Genet) 48: 466-478.
Wang QF, Li W, Yang Hai, Liu YL, Cao HH, Dornmayr-Pfaffenhuemer M, Stan-Lotter H, Guo GQ*, 2007, Halococcus qingdaonensis sp. nov., a halophilic archaeon isolated from a crude sea-salt sample. Int J Syst Evol Microbiol 57: 600-604.
Tiwari RK*, Trivedi M, Guang ZC, Guo GQ*, Zheng GC. 2007. Genetic transformation of Gentiana macrophylla with Agrobacterium rhizogenes: growth and production of secoiridoid glucoside gentiopicroside in transformed hairy root cultures. Plant Cell Rep 26: 199–210.
Guo GQ*, Zheng GC, 2004, Hypotheses for the functions of intercellular bridges in male germ cell development and its cellular mechanisms. J Theor Biol 229: 139-146.
Guo GQ, Maiwald F, Lorenzen P & Steinbiss HH, 1998, Factors influencing T-DNA transfer into wheat and barley cells by Agrobacterium tumefaciens. Cereal Res Comm 26: 15-22.
Guo GQ, Xia GM, Li ZY, Chen HM, 1991, Direct somatic embryogenesis and plant regeneration from protoplast-derived cells of wheat. Sci in China (ser B) 34: 438-45.

研究方向

1、 細胞分裂素和生長素相互作用 Auxin/cytokinin interactions

生長素和細胞分裂素是調(diào)控植物發(fā)育的兩類重要激素，其比例和相互作用決定著細胞生長和分化的命運。我們用分子遺傳學(xué)等相關(guān)技術(shù)研究細胞分裂素如何影響生長素生物合成及極性運輸進而調(diào)控植物的生長發(fā)育。

Auxin and cytokinin are the two classic plant hormones playing pivotal roles in plant development. It is a famous theme in plant science that the development of cells into roots or shoots is often determined by the ratio of auxin/cytokinin. We use molecular genetics to studies how cytokinin regulates auxin biosynthesis and its polar transport to influence plant development.

2. 生殖細胞發(fā)育 Germ cell development

植物的有性生殖涉及減數(shù)分裂（孢子發(fā)生）和配子體（花粉）發(fā)育，受到基因的精確調(diào)控并需要細胞間的相互協(xié)調(diào)。我們主要用擬南芥為材料分離突變體，用分子生物學(xué)手段研究小孢子發(fā)生和配子體發(fā)育的分子機理。
Sexual reproduction in plants occurs via meiosis (sporogenesis) and gametophyte development under strict genetic control with highly coordination between cells. We use the current powerful tools in cell and molecular biology to study the related molecular mechanisms through isolating mutants in Arabidopsis and cloning the corresponding genes.

項目成果

先后主持國家自然科學(xué)基金面上、重大研究計劃和重點項目，以及973項目子課題。目前主持2項國家自然基金在研項目：

（1）植物生長素合成及代謝缺陷突變體的系統(tǒng)篩選和研究（重點項目）；

（2）酰基轉(zhuǎn)移酶GFC1參與細胞分裂素信號轉(zhuǎn)導(dǎo)的生化和分子機理（面上）。

生長素和細胞分裂素是調(diào)控植物生長發(fā)育的重要激素，對它們作用機理的研究一直是國際上的熱點。

研究成果：（1）是國際上獨立發(fā)現(xiàn)生長素生物合成IPA途徑的突變體taa1的4家實驗室之一，并進一步獨立提出了細胞分裂素通過促進生長素合成并抑制其極性運輸?shù)淖饔脵C理調(diào)控植物發(fā)育[Plant J, 66, 516–527 (2011)]；(2）2004年提出胞間橋/通道功能假說（Guo & Zheng 2004），在國際上受到關(guān)注，被《Cell》、《PNAS》、《Trends Mol Med》、《Biol Rev》、《Cold Spring Harb Perspect Biol》和《Dev Biol》及相關(guān)專著所引用；（3）1990年在國際上公認為難度極大的小麥原生質(zhì)體培養(yǎng)中首先實現(xiàn)再生細胞直接形成體細胞胚和再生植株。

社會工作

2013：細胞研究所所長

2012：《西北植物學(xué)報》編委